caa a22 4500 465778305 CHVBK 20180323111948.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00935719 doi (NATIONALLICENCE)springer-10.1007/BF00935719 Stefansson Einar Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA aut Oxygen and diabetic eye disease [Elektronische Daten] [Einar Stefansson] In 1956, Wise suggested that retinal hypoxia stimulated retinal neovascularization in the ischemic proliferative retinopathies. Although not directly proven, this theory is strongly supported by a wealth of circumstantial information. Two treatment modalities, vitrectomy and panretinal photocoagulation, have been shown to be effective against retinal neovascularization in diabetics. Both of these treatment modalities improve retinal oxygenation, and we propose that this is the mechanism through which they halt retinal neovascularization. The mechanism for improving retinal oxygenation is different for the two treatment modalities. In the case of panretinal photocoagulation, the new oxygen supply comes from the choroid through the laser scar in the outer retina. In the case of vitrectomy, it comes from the vitreous cavity itself, but the end result is the same. We have expanded Wise's hypothesis to include these two treatment modalities, which were not known at the time of Wise's original paper. Springer-Verlag, 1990 Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/2(1990-03-01), 120-123 0721-832X 228:2<120 1990 228 417 https://doi.org/10.1007/BF00935719 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00935719 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Stefansson Einar Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/2(1990-03-01), 120-123 0721-832X 228:2<120 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 465777104 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer