caa a22 4500 465778321 CHVBK 20180323111948.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00935725 doi (NATIONALLICENCE)springer-10.1007/BF00935725 Vitreal and retinal oxygenation [Elektronische Daten] [Valerie Alder, Stephen Cringle] This paper reports the results of experiments carried out to understand the oxygenation of the normal retina in response to alterations in physiological conditions such as inspired oxygen concentration, elevated IOP, luminance changes and occlusion of the retinal circulation. Measurements of vitreal and intraretinal PO2 in vivo in the cat using oxygen-sensitive microelectrodes demonstrated that large PO2 gradients were set up preretinally and that arterial, venous and tissue PO2 increased when inspired PO2 was raised to 100% O2. Results showed that with an occluded retinal circulation, it was possible to oxygenate fully the whole retina with oxygen supplied from a hyperoxic choroidal circulation. With alterations in background luminance from photopic to scotopic, preretinal PO2 was unaffected for air breathing, whereas for 100% O2, breathing vitreal PO2 fell quickly and reversibly on a switch from photopic to scotopic conditions, reflecting an increase in retinal oxygen consumption in a dark environment. During acute rises of IOP, the PO2 at the choriocapillaris fell and an anoxic region developed in the middle retinal layers. The inner retina was relatively resistant to rises in IOP. The implications of these data for autoregulation of the retinal circulation are discussed. Springer-Verlag, 1990 Alder Valerie Lions Eye Institute and Department of Surgery, University of Western Australia, 6009, Nedlands, Western Australia, Australia aut Cringle Stephen Lions Eye Institute and Department of Surgery, University of Western Australia, 6009, Nedlands, Western Australia, Australia aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/2(1990-03-01), 151-157 0721-832X 228:2<151 1990 228 417 https://doi.org/10.1007/BF00935725 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00935725 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alder Valerie Lions Eye Institute and Department of Surgery, University of Western Australia, 6009, Nedlands, Western Australia, Australia aut NATIONALLICENCE 700 1- Cringle Stephen Lions Eye Institute and Department of Surgery, University of Western Australia, 6009, Nedlands, Western Australia, Australia aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/2(1990-03-01), 151-157 0721-832X 228:2<151 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 465777295 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer