caa a22 4500 465781721 CHVBK 20180323111957.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02935525 doi (NATIONALLICENCE)springer-10.1007/BF02935525 T-Cell receptor and autoimmune disease [Elektronische Daten] [Shinji Komori, Richard Siegel, Katsuyuki Yui, Makoto Katsumata, Mark Greene] Summary: Since the genes encoding the TCR have been cloned, their structure, organization, pattern of rearrangement, diversification and expression in ontogeny have been classified. However, there are still many important questions to be addressed, such as the nature of thymic education, tolerance, the mechanism of MHC-restricted antigen recognition and the relation between TCR repertoire and autoimmunity. In the future, new approaches to study these issues, such as transgenic mice, X-ray crystallography, and severe combined immune deficiency mice reconstituted with human hematopoietic cells will lead to a more profound understanding of these questions. This will hopefully allow us to manipulate the immune response in different and more effective ways than are currently available. Humana Press Inc., 1990 Komori Shinji Department of Pathology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pa, USA aut Siegel Richard Department of Pathology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pa, USA aut Yui Katsuyuki Department of Pathology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pa, USA aut Katsumata Makoto Department of Pathology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pa, USA aut Greene Mark Department of Pathology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pa, USA aut Immunologic Research Humana Press 9/4(1990-12-01), 245-264 0257-277X 9:4<245 1990 9 12026 https://doi.org/10.1007/BF02935525 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02935525 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Komori Shinji Department of Pathology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pa, USA aut NATIONALLICENCE 700 1- Siegel Richard Department of Pathology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pa, USA aut NATIONALLICENCE 700 1- Yui Katsuyuki Department of Pathology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pa, USA aut NATIONALLICENCE 700 1- Katsumata Makoto Department of Pathology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pa, USA aut NATIONALLICENCE 700 1- Greene Mark Department of Pathology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pa, USA aut NATIONALLICENCE 773 0- Immunologic Research Humana Press 9/4(1990-12-01), 245-264 0257-277X 9:4<245 1990 9 12026 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer