caa a22 4500 465781780 CHVBK 20180323111957.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02918199 doi (NATIONALLICENCE)springer-10.1007/BF02918199 Control of transcription at the murine Aα locus [Elektronische Daten] [Mark Boothby, Hsiou-Chi Liou, Patricia Finn, Ellen Gravallese, Laurie Glimcher] Conclusion: Our studies to date have implicated several separate DNA elements in Aα gene transcription in B cells: the conserved X-Y region and two related elements further upstream than the X-Y region. Important transcription elements for monocyte/macrophage lineage cells have tended to map much closer to the conserved region than those of B cells [45, 46]; however, we have not yet rigorously tested the control of Aα sequences in macrophages. We conclude from our data on the X box that each murine X box is bound by a different set of proteins, though the major complex generated with an Eα probe may have reflected binding by the same protein as the main Eβ complex [47]. Cloned cDNAs encoding Aα X box-X-Y interspace binding proteins [48] will further the analysis of transcription biochemistry for Aα. We also conclude that DNA sequences upstream from Aα are important in B-cell-specific cis-activation of transcription, that this function will at least in part be mediated by a DNA-binding protein that binds to two sites upstream from X and Y in Aα and that these sites will be essential for IL-4-induced increases in transcription. Tests of these observations will hopefully lead to a greater degree of understanding of the control of class II transcription, as well as of its failure in class II-deficient bare lymphocyte syndrome SCID patients. Humana Press Inc., 1990 Boothby Mark Department of Cancer Biology, Harvard School of Public Health, Harvard Medical School, 02115, Boston, MA, USA aut Liou Hsiou-Chi Department of Cancer Biology, Harvard School of Public Health, Harvard Medical School, 02115, Boston, MA, USA aut Finn Patricia Department of Cancer Biology, Harvard School of Public Health, Harvard Medical School, 02115, Boston, MA, USA aut Gravallese Ellen Department of Cancer Biology, Harvard School of Public Health, Harvard Medical School, 02115, Boston, MA, USA aut Glimcher Laurie Department of Cancer Biology, Harvard School of Public Health, Harvard Medical School, 02115, Boston, MA, USA aut Immunologic Research Humana Press 9/2(1990-06-01), 77-92 0257-277X 9:2<77 1990 9 12026 https://doi.org/10.1007/BF02918199 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02918199 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boothby Mark Department of Cancer Biology, Harvard School of Public Health, Harvard Medical School, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Liou Hsiou-Chi Department of Cancer Biology, Harvard School of Public Health, Harvard Medical School, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Finn Patricia Department of Cancer Biology, Harvard School of Public Health, Harvard Medical School, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Gravallese Ellen Department of Cancer Biology, Harvard School of Public Health, Harvard Medical School, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Glimcher Laurie Department of Cancer Biology, Harvard School of Public Health, Harvard Medical School, 02115, Boston, MA, USA aut NATIONALLICENCE 773 0- Immunologic Research Humana Press 9/2(1990-06-01), 77-92 0257-277X 9:2<77 1990 9 12026 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer