caa a22 4500 465781799 CHVBK 20180323111957.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02918203 doi (NATIONALLICENCE)springer-10.1007/BF02918203 Kaufman Jim Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005, Basel, (Switzerland) aut Evolution of the MHC: Lessons from the nonmammalian vertebrates [Elektronische Daten] [Jim Kaufman] Conclusions: Class I and class II genes diverged before the appearance of the amphibians; in fact the class II isotypes apparently also split before this time. It has been relatively easy to find xenoantisera which cross-react with recognizable MHC molecules in reptiles and amphibians, but not in fish. It is not clear whether this is due to high-sequence divergence, low abundance, unrecognizable biochemical properties or simple absence. At least one other highly polymorphic MHC-encoded cell surface multigene family exists in nonmammalian vertebrates: the disulfide-linked dimeric chicken B-G molecule. Molecules with superficial biochemical similarities are found in association with class I α chain in reptiles and amphibians. The roles of these molecules are yet to be discovered. Humana Press Inc., 1990 Immunologic Research Humana Press 9/2(1990-06-01), 123-134 0257-277X 9:2<123 1990 9 12026 https://doi.org/10.1007/BF02918203 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02918203 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kaufman Jim Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005, Basel, (Switzerland) aut NATIONALLICENCE 773 0- Immunologic Research Humana Press 9/2(1990-06-01), 123-134 0257-277X 9:2<123 1990 9 12026 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer