caa a22 4500 465783368 CHVBK 20180323112001.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02442610 doi (NATIONALLICENCE)springer-10.1007/BF02442610 Analysis of excitable cell activation: relative effects of external electrical stimuli [Elektronische Daten] [K. Altman, R. Plonsey] In the functional electrical stimulation of nerve an expression defined as the ‘activating function' has been introduced to evaluate the propensity for a particular fibre to excite. This approach to determine resulting activation is only an approximation as it neglects the presence of the fibres on the applied field, in contrast to activity determined from a rigorous solution to the core conductor/excitable membrane equations. An alternative approach to determining relative excitability based on the induced transmembrane potential is presented, thereby allowing for current redistribution via the space constant of the target fibre. The paper critically examines the approximations made with activating functions, and concludes that as currently formulated the activating function has limitations in predicting relative excitability under a number of important conditions. In contrast, it is the induced (passive) transmembrane potential that provides a quantitatively reliable estimate of the tendency for fibres to excite. IFMBE, 1990 Activating function nationallicence Functional electrical stimulation nationallicence Nerve/muscle activation nationallicence Theoretical electrophysiology nationallicence Altman K. Department of Biomedical Engineering, Duke University, 27706, Durham, NC, USA aut Plonsey R. Department of Biomedical Engineering, Duke University, 27706, Durham, NC, USA aut Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/6(1990-11-01), 574-580 0140-0118 28:6<574 1990 28 11517 https://doi.org/10.1007/BF02442610 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02442610 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Altman K. Department of Biomedical Engineering, Duke University, 27706, Durham, NC, USA aut NATIONALLICENCE 700 1- Plonsey R. Department of Biomedical Engineering, Duke University, 27706, Durham, NC, USA aut NATIONALLICENCE 773 0- Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/6(1990-11-01), 574-580 0140-0118 28:6<574 1990 28 11517 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer