caa a22 4500 465783449 CHVBK 20180323112001.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02442674 doi (NATIONALLICENCE)springer-10.1007/BF02442674 Weaver J. Harvard-MIT Division of Health Sciences & Technology, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut Sampling: a critical problem in biosensing [Elektronische Daten] [J. Weaver] Biosensing is widely recognised to be of potentially major importance to medicine and related fields, but in spite of a large number of impressive and important advances, widespread practical application has lagged. We examine the thesis that ‘sampling' is a process which involves all of the phenomena which are associated with the transport of analyte molecules to the active sensor site, and that problems associated with this process are now the limiting factor in further use of many existing biosensors. We conclude that an integrated process of sampling and sensing should be emphasised in developing new biosensing systems, and propose several new approaches. IFMBE, 1990 Analyte transport nationallicence Biosensor nationallicence Cell growth nationallicence Cell secretion nationallicence Diffusion nationallicence Gel microdroplet nationallicence Invasive sensor nationallicence Sampling nationallicence Sampling process nationallicence Thermal diffusion probe nationallicence Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/3(1990-05-01), B3-B9 0140-0118 28:3<B3 1990 28 11517 https://doi.org/10.1007/BF02442674 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02442674 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Weaver J. Harvard-MIT Division of Health Sciences & Technology, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut NATIONALLICENCE 773 0- Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/3(1990-05-01), B3-B9 0140-0118 28:3<B3 1990 28 11517 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer