caa a22 4500 465783457 CHVBK 20180323112001.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02442679 doi (NATIONALLICENCE)springer-10.1007/BF02442679 Rolfe P. Department of Biomedical Engineering & Medical Physics, University of Keele, Hospital Centre, Thornburrow Drive, Hartshill, ST4 7QB, Stoke-on-Trent, Staffs, UK aut In vivo chemical sensors for intensive-care monitoring [Elektronische Daten] [P. Rolfe] There is a need for rapid assessment of a patient's biochemical status during intensive care so that therapies may be optimised. Chemical sensors for key species have the potential to allow continuous in vivo monitoring, and some progress is being made with certain sensors. Gases, ions and certain catabolites such as glucose and urea may be measured with devices based on mass spectrometric, electrochemical or optical principles. The physical form, and size of sensors must be matched to the measurement site, which can include the airway, the intravascular space, tissue and the skin surface. Electrochemical sensors for measurement of O2, pH and glucose have been the most widely used to date, although fibre-optic devices are currently attracting considerable interest. Invasive sensors still suffer from the problem of poor biocompatibility, particularly devices used in arteries and veins. Noninvasive methods may be successful in certain circumstances and in some patient groups, but peripheral measurements are often significantly influenced by circulatory phenomena such as shock. Further research is required if these limitations of both invasive and noninvasive sensors are to be overcome and continuous chemical monitoring is to be established as a routine clinical technique. IFMBE, 1990 Biocompatability nationallicence Biosensors nationallicence Intensive care monitoring nationallicence In vivo sensors nationallicence Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/3(1990-05-01), B34-B47 0140-0118 28:3<B34 1990 28 11517 https://doi.org/10.1007/BF02442679 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02442679 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Rolfe P. Department of Biomedical Engineering & Medical Physics, University of Keele, Hospital Centre, Thornburrow Drive, Hartshill, ST4 7QB, Stoke-on-Trent, Staffs, UK aut NATIONALLICENCE 773 0- Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/3(1990-05-01), B34-B47 0140-0118 28:3<B34 1990 28 11517 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer