caa a22 4500 465783538 CHVBK 20180323112001.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02442680 doi (NATIONALLICENCE)springer-10.1007/BF02442680 Mechanical pathophysiology of some heart diseases: a theoretical model study [Elektronische Daten] [R. Beyar, S. Sideman] Sarcomere dynamics are related to the global left ventricular (LV) function in some representative pathological states, by using a theoretical model which combines sarcomere function, LV fibrous structure and geometry with the haemodynamic loading conditions. The analysis shows that pressure (concentric) hypertrophy due to hypertension or aortic stenosis is associated with an increase of the normal endocardial-to-epicardial gradient(s) of oxygen demand, which may be one of the causes for the development of endocardial fibrosis. The analysis also indicates that sarcomere shortening is relatively normal in compensated volume (eccentric) hypertrophy. Mitral stenosis demonstrates a case of decreased LV function, secondary to a chronic decrease in LV end diastolic volume, with sarcomeres that operate at their lowest length range. Conversely, the sarcomere function is depressed in cardiomyopathy; the heart's pumping function is maintained by appropriate adjustment mechanisms. However, the sarcomeres show minimal shortening and function at their highest length range with low (or zero) functional reserve. The study thus provides a quantitative tool that relates global LV function to local sarcomere dynamics in various pathological states. IFMBE, 1990 Cardiac nationallicence Left ventricle nationallicence Model nationallicence Pathophysiology nationallicence Beyar R. Department of Chemical & Biomedical Engineering, Julius Silver Institute of Biomedical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel aut Sideman S. Department of Chemical & Biomedical Engineering, Julius Silver Institute of Biomedical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel aut Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/3(1990-05-01), 237-248 0140-0118 28:3<237 1990 28 11517 https://doi.org/10.1007/BF02442680 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02442680 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beyar R. Department of Chemical & Biomedical Engineering, Julius Silver Institute of Biomedical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel aut NATIONALLICENCE 700 1- Sideman S. Department of Chemical & Biomedical Engineering, Julius Silver Institute of Biomedical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel aut NATIONALLICENCE 773 0- Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/3(1990-05-01), 237-248 0140-0118 28:3<237 1990 28 11517 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer