caa a22 4500 465783708 CHVBK 20180323112002.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02446147 doi (NATIONALLICENCE)springer-10.1007/BF02446147 Development of methods to analyse transcranial Doppler ultrasound signals recorded in microgravity [Elektronische Daten] [P. Vaitkus, K. Johnston, R. Bondar, F. Stein, P. Bascom, Ly Mo, M. Kassam, L. Chadwick, J. Mehi, R. Cobbold] During space flights, several clinical syndromes may be the result of changes in cerebral circulation. The purpose of the paper is to describe the development and initial evaluation of a system for recording, processing and displaying transcranial Doppler ultrasound (TCD) waveforms from the middle cerebral artery (MCA) in microgravity. Volunteers were repeatedly subjected to 15-20 s intervals of microgravity (‘near zero gravity') during flights on the KC-135 military aircraft. Continuous TCD recordings from the MCA were stored on magnetic tape. The paper describes the system that was developed to digitise the Doppler ultrasound data and markers that corresponded to the various levels of microgravity, obtain the maximum and mean Doppler waveforms, identify the waveforms and quantify them. The results demonstrate the feasibility of making TCD recordings in a microgravity environment and illustrate excellent performance of the system and its ease of operation. Quantitative waveform analysis of the recordings from the first subject studied in the supine position showed statistically significant changes in MCA velocity waveforms during microgravity. IFMBE, 1990 Microgravity nationallicence TCD nationallicence Transcranial Doppler ultrasound nationallicence Vaitkus P. The Institute of Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, M5S 1A4, Toronto, Ontario, Canada aut Johnston K. The Institute of Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, M5S 1A4, Toronto, Ontario, Canada aut Bondar R. The Canadian Space Agency, c/o National Research Council, Building M60, K1A 0R6, Ottawa, Ontario, Canada aut Stein F. The Maple-Lake Non-Invasive Vascular Laboratory, Farmington, New Mexico, USA aut Bascom P. The Canadian Space Agency, c/o National Research Council, Building M60, K1A 0R6, Ottawa, Ontario, Canada aut Mo Ly The Institute of Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, M5S 1A4, Toronto, Ontario, Canada aut Kassam M. Ryerson Polytechnic Institute, Toronto, Canada aut Chadwick L. Sunnybrook Medical Center, Toronto, Canada aut Mehi J. Medasonics, Mountain View, California, USA aut Cobbold R. The Institute of Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, M5S 1A4, Toronto, Ontario, Canada aut Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/4(1990-07-01), 306-311 0140-0118 28:4<306 1990 28 11517 https://doi.org/10.1007/BF02446147 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02446147 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vaitkus P. The Institute of Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, M5S 1A4, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Johnston K. The Institute of Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, M5S 1A4, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Bondar R. The Canadian Space Agency, c/o National Research Council, Building M60, K1A 0R6, Ottawa, Ontario, Canada aut NATIONALLICENCE 700 1- Stein F. The Maple-Lake Non-Invasive Vascular Laboratory, Farmington, New Mexico, USA aut NATIONALLICENCE 700 1- Bascom P. The Canadian Space Agency, c/o National Research Council, Building M60, K1A 0R6, Ottawa, Ontario, Canada aut NATIONALLICENCE 700 1- Mo Ly The Institute of Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, M5S 1A4, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Kassam M. Ryerson Polytechnic Institute, Toronto, Canada aut NATIONALLICENCE 700 1- Chadwick L. Sunnybrook Medical Center, Toronto, Canada aut NATIONALLICENCE 700 1- Mehi J. Medasonics, Mountain View, California, USA aut NATIONALLICENCE 700 1- Cobbold R. The Institute of Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, M5S 1A4, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/4(1990-07-01), 306-311 0140-0118 28:4<306 1990 28 11517 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer