caa a22 4500 465783848 CHVBK 20180323112002.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02441965 doi (NATIONALLICENCE)springer-10.1007/BF02441965 Changes in the distribution of ventricular ectopic beats in long-term electrocardiograms [Elektronische Daten] [M. Malik, J. Poloniecki, A. Camm] Only simple methods have been used to assess antiarrhythmic and proarrhythmic effects when comparing baseline and on-therapy Holter recordings taken from the same patient. The paper suggests a new method for definition of these effects based upon comparisons of statistical distributions of ectopic beats. The method is based on multiple random sampling of the recordings and on application of the Smirnov test to compare the samplings. The results of these multiple comparisons are subsequently evaluated using the chi-squared test. An analysis is reported of Holter recordings made on seven patients suffering from ventricular arrhythmia but with anatomically normal heart. In each patient, one baseline recording and one recording on each of three different drugs were made. The results show that the definition of proarrhythmic effects can be partly addressed in a precise mathematical way. The method can also detect a significant change in the character of arrhythmia which can neither be classified as antiarrhythmic nor as proarrhythmic. IFMBE, 1990 Antiarrhythmic drugs nationallicence Definition of proarrhythmia nationallicence Processing of Holter tapes nationallicence Malik M. Department of Cardiological Sciences, St George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut Poloniecki J. Department of Cardiological Sciences, St George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut Camm A. Department of Cardiological Sciences, St George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/5(1990-09-01), 423-430 0140-0118 28:5<423 1990 28 11517 https://doi.org/10.1007/BF02441965 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02441965 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Malik M. Department of Cardiological Sciences, St George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut NATIONALLICENCE 700 1- Poloniecki J. Department of Cardiological Sciences, St George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut NATIONALLICENCE 700 1- Camm A. Department of Cardiological Sciences, St George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut NATIONALLICENCE 773 0- Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/5(1990-09-01), 423-430 0140-0118 28:5<423 1990 28 11517 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer