caa a22 4500 465783899 CHVBK 20180323112003.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02441967 doi (NATIONALLICENCE)springer-10.1007/BF02441967 Spectral analysis and acoustic transmission of mitral and aortic valve closure sounds in dogs [Elektronische Daten] Part 4: Effect of modulating cardiac inotropy [L. Durand, Y. Langlois, T. Lanthier, R. Chiarella, P. Coppens, S. Carioto, S. Bertrand-Bradley] A surgical protocol was designed to implant in dogs a programmable atrioventricular pacemaker and to destroy the bundle of His with one to four 0·1 ml formaldehyde injections. The heart rate and P-R interval were paced at 100 beats min−1 and 75 ms, respectively. Cardiac inotropy was then varied in five animals by using injections or infusions of cardiotonic drugs (Dobutamine, Betalol and Quinidine). Their effect on the spectra and acoustic transmission of the mitral M1 and aortic A2 closure sound components produced within the left heart and transmitted up to the body surface was studied. Results indicate that changes in cardiac inotropy strongly modify the intensity of M1 and A2 but do not markedly affect their spectral distribution. They also affect the transfer function of the heart/thorax acoustic system, but this influence is small compared with that of a 12 min reference interval. In addition, it was shown that the intensity of M1 is more sensitive to the cardiotonic agents than the intensity of A2. IFMBE, 1990 Aortic valve nationallicence Cardiac inotropy nationallicence Heart sounds nationallicence Heart-thorax acoustic system nationallicence Mitral valve nationallicence Spectral analysis nationallicence Durand L. Laboratory of Biomedical Engineering, Clinical Research Institute of Montreal, University of Montreal, 110 West Pine Avenue, H2W IR7, Montreal, Quebec, Canada aut Langlois Y. Laboratory of Biomedical Engineering, Clinical Research Institute of Montreal, University of Montreal, 110 West Pine Avenue, H2W IR7, Montreal, Quebec, Canada aut Lanthier T. Department of Medicine, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte Street, J2S 7C6, St-Hyacinthe, Quebec, Canada aut Chiarella R. Laboratory of Biomedical Engineering, Clinical Research Institute of Montreal, University of Montreal, 110 West Pine Avenue, H2W IR7, Montreal, Quebec, Canada aut Coppens P. Department of Medicine, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte Street, J2S 7C6, St-Hyacinthe, Quebec, Canada aut Carioto S. Department of Surgery, Hôtel-Dieu de Montréal Hospital, 3840 St-Urbain, H2W 1T8, Montreal, Quebec, Canada aut Bertrand-Bradley S. Medtronic of Canada, 1 Place du Commerce, Suite 170, Ile des Soeurs, H3E 1A2, Verdun, Quebec, Canada aut Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/5(1990-09-01), 439-445 0140-0118 28:5<439 1990 28 11517 https://doi.org/10.1007/BF02441967 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02441967 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Durand L. Laboratory of Biomedical Engineering, Clinical Research Institute of Montreal, University of Montreal, 110 West Pine Avenue, H2W IR7, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Langlois Y. Laboratory of Biomedical Engineering, Clinical Research Institute of Montreal, University of Montreal, 110 West Pine Avenue, H2W IR7, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Lanthier T. Department of Medicine, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte Street, J2S 7C6, St-Hyacinthe, Quebec, Canada aut NATIONALLICENCE 700 1- Chiarella R. Laboratory of Biomedical Engineering, Clinical Research Institute of Montreal, University of Montreal, 110 West Pine Avenue, H2W IR7, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Coppens P. Department of Medicine, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte Street, J2S 7C6, St-Hyacinthe, Quebec, Canada aut NATIONALLICENCE 700 1- Carioto S. Department of Surgery, Hôtel-Dieu de Montréal Hospital, 3840 St-Urbain, H2W 1T8, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Bertrand-Bradley S. Medtronic of Canada, 1 Place du Commerce, Suite 170, Ile des Soeurs, H3E 1A2, Verdun, Quebec, Canada aut NATIONALLICENCE 773 0- Medical and Biological Engineering and Computing Kluwer Academic Publishers 28/5(1990-09-01), 439-445 0140-0118 28:5<439 1990 28 11517 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 465783155 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer