caa a22 4500 465784771 CHVBK 20180323112005.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00811438 doi (NATIONALLICENCE)springer-10.1007/BF00811438 Effect of reserpine on the brain uptake of carbon 11 methamphetamine and its N -propagyl derivative, deprenyl [Elektronische Daten] [Osamu Inoue, Svante Axelsson, Hans Lundgvist, Lars Oreland, Bengt Långström] The enantiomers of methamphetamine (MAMP) and itsN-propagyl derivative, deprenyl, were labelled with carbon 11, and the tissue distribution of these labelled compounds in mice was studied. Both enantiomers of11C-MAMP rapidly entered into the brain and then disappeared according to a single exponential curve. The enantiomers of11C-deprenyl were also rapidly distributed to various organs in the same manner. With regard to elimination, however, a stereoselective, long-term retention of radioactivity in the brain, heart and lung, due to its irreversible binding with monoamine oxidase B, was observed forl-11C-deprenyl. In reserpinized mice, the initial brain uptake of both thel andd forms of11C-MAMP was significantly decreased. On the other hand, the brain uptake of both enantiomers of11C-deprenyl was slightly increased by pretreatment with reserpine. A significant and non-stereoselective elevation of the lung uptake of11C-deprenyl was also seen in reserpinized mice. In addition, both the relative tissue distribution and ratios of radioactivity in the brain compared with blood or heart at 1 and 5 min after the injection of11C-labelled methanol in mice were not changed by reserpine. These results indicate that the transport or binding processes of these amines rather than the blood flow might be altered by reserpine. There would be an important role of the pKa values of amines in both processes. The reduction of brain uptake as well as the change in ratio between brain and heart ofl-11C-MAMP in reserpinized mice 1 min after injection were reversed by treatment with amphetamine in a dose-related manner. D-Amphetamine was found to be several times more potent than the correspondingl-form in this regard. The present results reveal some possibility that the transport or binding processes of MAMP in the brain may be regulated by cathecholaminergic neurotransmission. Springer-Verlag, 1990 Methamphetamine nationallicence Deprenyl nationallicence Carbon II nationallicence Reserpine nationallicence Brain nationallicence Amphetamine nationallicence Stereoisomers nationallicence Inoue Osamu Division of Clinical Research, National Institute of Radiological Sciences, 49-1 Anagawa, 260, Chiba-shi, Japan aut Axelsson Svante Department of Organic Chemistry, Institute of Chemistry, Sweden aut Lundgvist Hans The Svedberg Laboratory, Sweden aut Oreland Lars Department of Medical Pharmacology, University of Uppsala, Box 531, S-751, 21, Uppsala, Sweden aut Långström Bengt Department of Organic Chemistry, Institute of Chemistry, Sweden aut European Journal of Nuclear Medicine Springer-Verlag 17/3-4(1990-03-01), 121-126 0340-6997 17:3-4<121 1990 17 259 https://doi.org/10.1007/BF00811438 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00811438 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inoue Osamu Division of Clinical Research, National Institute of Radiological Sciences, 49-1 Anagawa, 260, Chiba-shi, Japan aut NATIONALLICENCE 700 1- Axelsson Svante Department of Organic Chemistry, Institute of Chemistry, Sweden aut NATIONALLICENCE 700 1- Lundgvist Hans The Svedberg Laboratory, Sweden aut NATIONALLICENCE 700 1- Oreland Lars Department of Medical Pharmacology, University of Uppsala, Box 531, S-751, 21, Uppsala, Sweden aut NATIONALLICENCE 700 1- Långström Bengt Department of Organic Chemistry, Institute of Chemistry, Sweden aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 17/3-4(1990-03-01), 121-126 0340-6997 17:3-4<121 1990 17 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer