caa a22 4500 465784860 CHVBK 20180323112005.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00819399 doi (NATIONALLICENCE)springer-10.1007/BF00819399 Mechanism of gallium 67 accumulation in inflammatory tissue [Elektronische Daten] [Atsushi Ando, Kazuo Nitta, Itsuko Ando, Shigeru Sanada, Shogo Katsuda, Norihisa Tonami, Tatsunosuke Hiraki, Kinichi Hisada, Hiroshi Ogawa] The present study was undertaken to elucidate the accumulation mechanism of gallium 67 in inflammatory tissue.67Ga accumulation in inflammatory tissue was observed by macro- and microautoradiogram. Permeability indices were calculated for serum albumin from blood vessels into inflammatory and normal tissue. Neutrophils and macrophages did not play a major role in67Ga accumulation in the inflammatory tissue because67Ga could hardly be detected in the sites in which neutrophils were crowded; the accumulation was concentrated in the intercellular space around these cells in the tissue. Permeability indices for inflammatory tissue were much greater than those for normal tissues. It is thought from the present study and previously reported results that67Ga, together with plasma from permeable blood vessels, readily penetrates the inflammatory tissue and stays there by binding to the acid mucopolysaccharide present in the tissue. Springer-Verlag, 1990 Gallium 67 nationallicence Inflammation nationallicence Accumulation mechanism nationallicence Permeability indices nationallicence Acid mucopolysaccharide nationallicence Ando Atsushi School of Allied Medical Professions, Kanazawa University, 5-11-80, Kodatsuno, 920, Kanazawa, Japan aut Nitta Kazuo Daiichi Radioisotope Laboratories Ltd., Tokyo, Japan aut Ando Itsuko School of Allied Medical Professions, Kanazawa University, 5-11-80, Kodatsuno, 920, Kanazawa, Japan aut Sanada Shigeru School of Allied Medical Professions, Kanazawa University, 5-11-80, Kodatsuno, 920, Kanazawa, Japan aut Katsuda Shogo School of Medicine, Kanazawa University, Kanazawa, Japan aut Tonami Norihisa School of Medicine, Kanazawa University, Kanazawa, Japan aut Hiraki Tatsunosuke School of Allied Medical Professions, Kanazawa University, 5-11-80, Kodatsuno, 920, Kanazawa, Japan aut Hisada Kinichi School of Medicine, Kanazawa University, Kanazawa, Japan aut Ogawa Hiroshi Daiichi Radioisotope Laboratories Ltd., Tokyo, Japan aut European Journal of Nuclear Medicine Springer-Verlag 17/1-2(1990-01-01), 21-27 0340-6997 17:1-2<21 1990 17 259 https://doi.org/10.1007/BF00819399 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00819399 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ando Atsushi School of Allied Medical Professions, Kanazawa University, 5-11-80, Kodatsuno, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Nitta Kazuo Daiichi Radioisotope Laboratories Ltd., Tokyo, Japan aut NATIONALLICENCE 700 1- Ando Itsuko School of Allied Medical Professions, Kanazawa University, 5-11-80, Kodatsuno, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Sanada Shigeru School of Allied Medical Professions, Kanazawa University, 5-11-80, Kodatsuno, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Katsuda Shogo School of Medicine, Kanazawa University, Kanazawa, Japan aut NATIONALLICENCE 700 1- Tonami Norihisa School of Medicine, Kanazawa University, Kanazawa, Japan aut NATIONALLICENCE 700 1- Hiraki Tatsunosuke School of Allied Medical Professions, Kanazawa University, 5-11-80, Kodatsuno, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Hisada Kinichi School of Medicine, Kanazawa University, Kanazawa, Japan aut NATIONALLICENCE 700 1- Ogawa Hiroshi Daiichi Radioisotope Laboratories Ltd., Tokyo, Japan aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 17/1-2(1990-01-01), 21-27 0340-6997 17:1-2<21 1990 17 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer