caa a22 4500 465784984 CHVBK 20180323112006.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00819408 doi (NATIONALLICENCE)springer-10.1007/BF00819408 Semi-automatic quantification of regional cerebral perfusion in primary degenerative dementia using 99m technetium-hexamethylpropylene amine oxime and single photon emission tomography [Elektronische Daten] [Peter Goulding, Attila Burjan, Robin Smith, Richard Lawson, Julie Snowden, Bernice Northen, David Neary, Humberto Testa] A new semi-automatic method for quantifying regional cerebral uptake of 99m technetium-hexamethylpropylene amine oxime (99mTc-HMPAO) was used to assess single photon emission tomograms from 5 normal subjects, 14 patients with Alzheimer's disease, 14 patients with dementia of frontal lobe type and 4 patients with dementia with motor neurone disease. Uptake in both posterior cortical regions, although not in other regions, was significantly lower (P < 0.05) in Alzheimer's disease than in normal controls. Conversely in both dementia of frontal lobe type and dementia with motor neurone disease, uptake was significantly reduced (P < 0.05) compared with controls in all anterior cortical regions but not in posterior regions. Numerical findings in each disease mirrored the pattern of reduced tracer uptake previously reported by visual assessment. Nine patients were re-examined after an interval of at least 1 year. Comparison of follow-up scans with original images showed significant decreases in mid-anterior, left anterior and left posterior cortical uptake (P < 0.01) in patients with Alzheimer's disease and in left middle, left posterior and right posterior cortical uptake (P < 0.01) in patients with dementia of frontal lobe type. The method of quantification may be a useful adjunct to the visual assessment of single photon emission tomograms. Springer-Verlag, 1990 Semi-automatic quantification nationallicence Cerebral perfusion nationallicence 99m technetium-hexamethylpropylene amine oxime nationallicence Primary degenerative dementia nationallicence Goulding Peter Department of Neurology, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut Burjan Attila Department of Medical Physics, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut Smith Robin Department of Medical Physics, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut Lawson Richard Department of Medical Physics, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut Snowden Julie Department of Neurology, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut Northen Bernice Department of Neurology, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut Neary David Department of Neurology, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut Testa Humberto Department of Nuclear Medicine, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut European Journal of Nuclear Medicine Springer-Verlag 17/1-2(1990-01-01), 77-82 0340-6997 17:1-2<77 1990 17 259 https://doi.org/10.1007/BF00819408 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00819408 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goulding Peter Department of Neurology, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut NATIONALLICENCE 700 1- Burjan Attila Department of Medical Physics, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut NATIONALLICENCE 700 1- Smith Robin Department of Medical Physics, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut NATIONALLICENCE 700 1- Lawson Richard Department of Medical Physics, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut NATIONALLICENCE 700 1- Snowden Julie Department of Neurology, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut NATIONALLICENCE 700 1- Northen Bernice Department of Neurology, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut NATIONALLICENCE 700 1- Neary David Department of Neurology, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut NATIONALLICENCE 700 1- Testa Humberto Department of Nuclear Medicine, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 17/1-2(1990-01-01), 77-82 0340-6997 17:1-2<77 1990 17 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer