caa a22 4500 46578500X CHVBK 20180323112006.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00819403 doi (NATIONALLICENCE)springer-10.1007/BF00819403 Dosimetry of intrathecal iodine131 monoclonal antibody in cases of neoplastic meningitis [Elektronische Daten] [R. Richardson, J. Kemshead, A. Davies, G. Staddon, P. Jackson, H. Coakham, L. Lashford] Radioiodinated monoclonal antibodies (MCA) were administered by the lumbar route into the cerebrospinal fluid (CSF) of four patients with malignant leptomeningeal disease. Evidence suggesting uptake of131I-MCA by tumour sites was seen in scintigrams. Dosimetry calculations were carried out, assuming that a proportion of the administered radionuclide was bound as a thin layer on the CSF surfaces of the meninges. The percentage injected dose and the clearance curves for the head and four spinal segments were obtained by scintigraphy after administration of tracer amounts of131I-MCA (7-18 MBq). Although radioisotope levels in the central nervous system (CNS) fell, as determined by both external scintillation counting and direct CSF sampling, a marked difference in the measurements developed with respect to time. The ratio of these two measurements reached a maximum of 49:1, 7 days after monoclonal antibody administration. Patients subsequently received therapeutic amounts (870-1600 MBq) of131I-MCAs, resulting in clinical remissions and prolonged survival. The mean absorbed radiation dose was estimated as 3.9 cGy·MBq−1 to the thoraco-lumbar region of the spine and 0.51 cGy·MBq−1 to the outer surface of the brain. The maximal dose delivered to the surface of the CNS in the region of the spine and brain was 5800 and 600 cGy, respectively. Springer-Verlag, 1990 Dosimetry nationallicence Radioiodine nationallicence Monoclonal antibodies nationallicence Intrathecal and CSF therapy nationallicence Richardson R. Department of Medical Physics, Frenchay Hospital and Bristol General Hospital, Bristol, UK aut Kemshead J. Imperial Cancer Research Fund, Paediatic and Neuro-Oncology Group, Frenchay Hospital, Bristol, UK aut Davies A. Brain Tumour Research Laboratory, Department of Neurosurgery, Frenchay Hospital, BS16 1LE, Bristol, UK aut Staddon G. Department of Medical Physics, Frenchay Hospital and Bristol General Hospital, Bristol, UK aut Jackson P. Department of Medical Physics, Frenchay Hospital and Bristol General Hospital, Bristol, UK aut Coakham H. Brain Tumour Research Laboratory, Department of Neurosurgery, Frenchay Hospital, BS16 1LE, Bristol, UK aut Lashford L. Imperial Cancer Research Fund, Paediatic and Neuro-Oncology Group, Frenchay Hospital, Bristol, UK aut European Journal of Nuclear Medicine Springer-Verlag 17/1-2(1990-01-01), 42-48 0340-6997 17:1-2<42 1990 17 259 https://doi.org/10.1007/BF00819403 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00819403 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Richardson R. Department of Medical Physics, Frenchay Hospital and Bristol General Hospital, Bristol, UK aut NATIONALLICENCE 700 1- Kemshead J. Imperial Cancer Research Fund, Paediatic and Neuro-Oncology Group, Frenchay Hospital, Bristol, UK aut NATIONALLICENCE 700 1- Davies A. Brain Tumour Research Laboratory, Department of Neurosurgery, Frenchay Hospital, BS16 1LE, Bristol, UK aut NATIONALLICENCE 700 1- Staddon G. Department of Medical Physics, Frenchay Hospital and Bristol General Hospital, Bristol, UK aut NATIONALLICENCE 700 1- Jackson P. Department of Medical Physics, Frenchay Hospital and Bristol General Hospital, Bristol, UK aut NATIONALLICENCE 700 1- Coakham H. Brain Tumour Research Laboratory, Department of Neurosurgery, Frenchay Hospital, BS16 1LE, Bristol, UK aut NATIONALLICENCE 700 1- Lashford L. Imperial Cancer Research Fund, Paediatic and Neuro-Oncology Group, Frenchay Hospital, Bristol, UK aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 17/1-2(1990-01-01), 42-48 0340-6997 17:1-2<42 1990 17 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer