caa a22 4500 465785077 CHVBK 20180323112006.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF01268024 doi (NATIONALLICENCE)springer-10.1007/BF01268024 Donor leucocyte imaging in patients with AIDS: a preliminary report [Elektronische Daten] [Michael O'Doherty, Paul Revell, Christopher Page, Susan Lee, Peter Mountford, Thomas Nunan] Four patients with the acquired immunodeficiency syndrome (AIDS) and fever were investigated using donor leucocyte scans. The lung/liver and lung/spleen uptake ratios in these patients were compared with the uptake ratios in donor leucocyte scans in seven neutropenic (non-AIDS) patients and five patients who had autologous leucocyte scans performed over the same time period. For all scans indium-111-oxime-labelled leucocytes were used, except for one AIDS patient in whom technetium-99m hexamethyl-propylene amine oxide (HMPAD)-labelled donor leucocytes were used. There were no adverse reactions to the donor cell infusions. Two patients had repeat studies 8 weeks apart (from different donors) without ill effect. There were no differences in the111In uptake ratios between the three groups. There were three positive studies in the patients with AIDS, and these elucidated the cause of the pyrexia in all three. The negative case is more difficult to confirm, but the clinical course and the absence of focal disease on post-mortem have been taken to support the scan findings. There was no difference in the acceptability of the technique or the distribution of the labelled leucocytes between the AIDS and non-AIDS patients. Donor leucocyte imaging of patients with AIDS is probably more effective and considerably less hazardous for technical staff than autologous leucocyte methods. This study demonstrates that the technique can be applied successfully to patients with AIDS. Springer-Verlag, 1990 Leucocyte scan nationallicence Indium nationallicence Hexamethyl-propylene amine oxide nationallicence Acquired immunodeficiency syndrome nationallicence O'Doherty Michael Department of Nuclear Medicine, Rayne Institute, St. Thomas' Hospital, SE1 7EH, London, UK aut Revell Paul Department of Haemophilia, Rayne Institute, St. Thomas' Hospital, SE1 7EH, London, UK aut Page Christopher Department of Nuclear Medicine, Rayne Institute, St. Thomas' Hospital, SE1 7EH, London, UK aut Lee Susan Department of Radiopharmacy, Rayne Institute, St. Thomas' Hospital, SE1 7EH, London, UK aut Mountford Peter Department of Nuclear Medicine, Kent and Canterbury Hospital, Canterbury, Kent, UK aut Nunan Thomas Department of Nuclear Medicine, Rayne Institute, St. Thomas' Hospital, SE1 7EH, London, UK aut European Journal of Nuclear Medicine Springer-Verlag 17/6-8(1990-06-01), 327-333 0340-6997 17:6-8<327 1990 17 259 https://doi.org/10.1007/BF01268024 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01268024 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- O'Doherty Michael Department of Nuclear Medicine, Rayne Institute, St. Thomas' Hospital, SE1 7EH, London, UK aut NATIONALLICENCE 700 1- Revell Paul Department of Haemophilia, Rayne Institute, St. Thomas' Hospital, SE1 7EH, London, UK aut NATIONALLICENCE 700 1- Page Christopher Department of Nuclear Medicine, Rayne Institute, St. Thomas' Hospital, SE1 7EH, London, UK aut NATIONALLICENCE 700 1- Lee Susan Department of Radiopharmacy, Rayne Institute, St. Thomas' Hospital, SE1 7EH, London, UK aut NATIONALLICENCE 700 1- Mountford Peter Department of Nuclear Medicine, Kent and Canterbury Hospital, Canterbury, Kent, UK aut NATIONALLICENCE 700 1- Nunan Thomas Department of Nuclear Medicine, Rayne Institute, St. Thomas' Hospital, SE1 7EH, London, UK aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 17/6-8(1990-06-01), 327-333 0340-6997 17:6-8<327 1990 17 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer