caa a22 4500 465785131 CHVBK 20180323112007.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF01268025 doi (NATIONALLICENCE)springer-10.1007/BF01268025 Pulmonary clearance of technetium 99m diethylene triamine penta-acetic acid aerosol in patients with amiodarone pneumonitis [Elektronische Daten] [Mario Terra-Filho, Francisco Vargas, J. Meneguetti, Jose Soares Jr., Alberto Cukier, Lisete Teixeira, Edwaldo Camargo] Amiodarone pneumonitis is a serious complication that may lead to fatal lung fibrosis. In an attempt to diagnose this condition as early as possible, the technetium-99m-labelled diethylene triamine penta-acetic acid (99mTc-DTPA) aerosol washout rates of 10 non-smoking normal volunteers (group 1), 10 non-smoking patients on a long-term amiodarone regimen with dilated cardiomyopathy but no congestive heart failure (group II) and 10 patients with amiodarone pneumonitis (group III) were compared. Spirometric measurements, as percentage predicted, were higher in group I than in group III (P < 0.05). The global mean effective half-lives of99mTc-DTPA aerosol for both lungs together in minutes were 65 ± 14, 55 ± 16 and 27 ± 4 for groups I, II and III, respectively. Group III values were significantly lower than those of groups I and II (P<0.05). Our results demonstrated that amiodarone pneumonitis alters the alveolar-capillary membrane permeability to hydrophilic molecules. The pulmonary clearance of99mTc-DTPA aerosol is a useful test in the differentiation of patients on a long-term amiodarone regimen without side effects from patients with amiodarone pneumonitis. The test is rapid, easy to perform and has the potential for playing an important role in deciding which patients should discontinue therapy. Springer-Verlag, 1990 Technetium 99m diethylene triamine penta-acetic acid nationallicence Amiodarone nationallicence Pneumonitis nationallicence Pulmonary aerosol clearance nationallicence Terra-Filho Mario The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut Vargas Francisco The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut Meneguetti J. The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut Soares Jr. Jose The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut Cukier Alberto The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut Teixeira Lisete The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut Camargo Edwaldo The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut European Journal of Nuclear Medicine Springer-Verlag 17/6-8(1990-06-01), 334-337 0340-6997 17:6-8<334 1990 17 259 https://doi.org/10.1007/BF01268025 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01268025 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Terra-Filho Mario The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut NATIONALLICENCE 700 1- Vargas Francisco The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut NATIONALLICENCE 700 1- Meneguetti J. The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut NATIONALLICENCE 700 1- Soares Jr Jose The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut NATIONALLICENCE 700 1- Cukier Alberto The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut NATIONALLICENCE 700 1- Teixeira Lisete The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut NATIONALLICENCE 700 1- Camargo Edwaldo The Heart Institute, Sao Paulo University School of Medicine, Sao Paulo, Brazil aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 17/6-8(1990-06-01), 334-337 0340-6997 17:6-8<334 1990 17 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer