caa a22 4500 465785301 CHVBK 20180323112007.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00812368 doi (NATIONALLICENCE)springer-10.1007/BF00812368 Whole-body distribution of iodine 123 metaiodobenzylguanid1ne in hypertrophic cardiomyopathy: significance of its washout from the heart [Elektronische Daten] [Junichi Taki, Kenichi Nakajima, Hisashi Bunko, Masami Simizu, Akira Muramori, Kinichi Hisada] Whole-body distribution of iodine 123 metaiodobenzylguanidine (123I-mIBG) was evaluated in 27 patients with hypertrophic cardiomyopathy (HCM). At 1 and 4 h after injection, anterior and posterior whole body images were obtained with a dual-headed, camera computer system. Patients were classified into three groups based on the septal wall thickness as determined by echocardiography: group 1 consisted of 7 patients with ≤ 15 mm septal thickness, group 2 included 12 patients with 16-19 mm septal thickness, and group 3 included 6 patients with ≽ 20 mm septal thickness. Although the myocardial mIBG uptakes at 1 h were similar among these groups (1.84% ± 0.19%, 1.95% ± 0.38%, 1.98% ± 0.57%, respectively; NS), mIBG washout from the heart in group 3 was faster than in groups 1 and 2 (31.5% ± 13.0% vs. 15.8% ± 11.0% (group 1,P < 0.05), 17.6% ± 7.3% (group 2,P < 0.01)). There was a significant positive correlation between mIBG washout from the heart and septal thickness, with correlation coefficientr=0.52 (P < 0.01). The liver, lung, parotid gland, spleen and skeletal muscle showed similar mIBG uptake and washout among the three groups. We conclude from these data that mIBG washout from the heart in HCM was faster in patients with severe hypertrophy than in patients with mild to moderate hypertrophy, and hence it may be a useful parameter for evaluating the severity of altered adrenergic innervation and activities. Springer-Verlag, 1990 Iodine 123 metaiodobenzylguanidine nationallicence Myocardial scintigraphy nationallicence Hypertrophic cardiomyopathy nationallicence Sympathetic nervous system nationallicence Taki Junichi Department of Nuclear Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut Nakajima Kenichi Department of Nuclear Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut Bunko Hisashi Department of Nuclear Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut Simizu Masami The Second Department of Internal Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut Muramori Akira Department of Nuclear Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut Hisada Kinichi Department of Nuclear Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut European Journal of Nuclear Medicine Springer-Verlag 17/5(1990-05-01), 264-268 0340-6997 17:5<264 1990 17 259 https://doi.org/10.1007/BF00812368 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00812368 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Taki Junichi Department of Nuclear Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Nakajima Kenichi Department of Nuclear Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Bunko Hisashi Department of Nuclear Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Simizu Masami The Second Department of Internal Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Muramori Akira Department of Nuclear Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Hisada Kinichi Department of Nuclear Medicine, Kanazawa University, School of Medicine, 13-1 Takara-machi, 920, Kanazawa, Japan aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 17/5(1990-05-01), 264-268 0340-6997 17:5<264 1990 17 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer