caa a22 4500 465785360 CHVBK 20180323112007.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00812363 doi (NATIONALLICENCE)springer-10.1007/BF00812363 Measurement of cerebral blood flow with a bolus of oxygen-15-labelled water: Comparison of dynamic and integral methods [Elektronische Daten] [A. Bol, P. Vanmelckenbeke, C. Michel, M. Cogneau, A. Goffinet] A method is presented for the measurement of cerebral blood flow (CBF) with a bolus of water labelled with oxygen 15. The method, which has been evaluated in normal volunteers, is based on Kety's model, with two additional parameters to account for the difference in the time of tracer arrival in the radial and carotid arteries ("delay”) and for dispersion of the tracer in the body and/or blood counting systems. It combines the advantages of: (i) dynamic data collection for estimation of delay and dispersion; (ii) robustness and linearity of CBF estimates with an integral method; and (iii) simplicity of continuous external monitoring of arterial blood radioactivity, particularly with repeated measurements. An optimized protocol is proposed for routine applications in neurological and neurophysiological studies. Springer-Verlag, 1990 Cerebral blood flow nationallicence Positron nationallicence Labelled water nationallicence Bol A. Positron Tomography Laboratory, University of Louvain, 2, Chemin du Cyclotron, B-1348, Louvain-la-Neuve, Belgium aut Vanmelckenbeke P. Positron Tomography Laboratory, University of Louvain, 2, Chemin du Cyclotron, B-1348, Louvain-la-Neuve, Belgium aut Michel C. Positron Tomography Laboratory, University of Louvain, 2, Chemin du Cyclotron, B-1348, Louvain-la-Neuve, Belgium aut Cogneau M. Positron Tomography Laboratory, University of Louvain, 2, Chemin du Cyclotron, B-1348, Louvain-la-Neuve, Belgium aut Goffinet A. Positron Tomography Laboratory, University of Louvain, 2, Chemin du Cyclotron, B-1348, Louvain-la-Neuve, Belgium aut European Journal of Nuclear Medicine Springer-Verlag 17/5(1990-05-01), 234-241 0340-6997 17:5<234 1990 17 259 https://doi.org/10.1007/BF00812363 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00812363 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bol A. Positron Tomography Laboratory, University of Louvain, 2, Chemin du Cyclotron, B-1348, Louvain-la-Neuve, Belgium aut NATIONALLICENCE 700 1- Vanmelckenbeke P. Positron Tomography Laboratory, University of Louvain, 2, Chemin du Cyclotron, B-1348, Louvain-la-Neuve, Belgium aut NATIONALLICENCE 700 1- Michel C. Positron Tomography Laboratory, University of Louvain, 2, Chemin du Cyclotron, B-1348, Louvain-la-Neuve, Belgium aut NATIONALLICENCE 700 1- Cogneau M. Positron Tomography Laboratory, University of Louvain, 2, Chemin du Cyclotron, B-1348, Louvain-la-Neuve, Belgium aut NATIONALLICENCE 700 1- Goffinet A. Positron Tomography Laboratory, University of Louvain, 2, Chemin du Cyclotron, B-1348, Louvain-la-Neuve, Belgium aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 17/5(1990-05-01), 234-241 0340-6997 17:5<234 1990 17 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer