caa a22 4500 465785379 CHVBK 20180323112007.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00812361 doi (NATIONALLICENCE)springer-10.1007/BF00812361 Multi-centre immunoscintigraphic study using indium-111-labelled CEA-specific and/or 19-9 monoclonal antibody F(ab′)2 fragments [Elektronische Daten] [A. Chetanneau, R. Baum, P. Lehur, J. Liehn, A. Perkins, R. Bares, P. Bourguet, J. Herry, J. Saccavini, J. Chatal] Six European nuclear medicine centres per formed immunoscintigraphy first retrospectively in 34 patients using indium-111-labelled carcinoembryonic antigen (CEA)-specific and/or 19-9 F(ab')2 fragments. Results for sensitivity and specificity in tumour sites were 94% and 87%, respectively, for the pelvis and 73% and 100% for the extrahepatic abdomen. A second prospective series concerned 58 other patients previously operated on for colorectal adenocarcinoma (27 colon, 31 rectum). Two-thirds of these patients had a suspected recurrence signalled by an isolated rise in tumour markers, and 46 patients examined by immunoscintigraphy, X-ray computed tomography and ultrasonography were found to have a recurrence (a total of 62 tumour sites). Sensitivity and specificity with immunoscintigraphy were 90% and 97%, respectively, for the pelvis and 62% and 95% for the extrahepatic abdomen. For 29 patients injected with CEA-specific fragments, sensitivity was 90% and specificity 94% for the pelvis. For 25 patients injected with 19-9 fragments, pelvic sensitivity and specificity were 80% and 100%, respectively, whereas sensitivity for the extrahepatic abdomen was only 29% since several cases of peritoneal carcinosis were not visualized. In the prospective series, comparison of the three imaging techniques for all tumour sites (including liver and in 5 cases thorax) gave a sensitivity and specificity of 82% and 91 %, respectively, for immunoscintigraphy, 52% and 95% for X-ray computed tomography and 59% and 100% for ultrasonography. These results thus confirm the advantage of using111In-labelled CEA-specific or 19-9 to visualize and localize recurrences of colorectal cancer. Springer-Verlag, 1990 Monoclonal antibodies nationallicence Fragments nationallicence Indium 111 nationallicence Colorectal carcinoma nationallicence Chetanneau A. Centre René Gauducheau and INSERM Research Unit 211, Quai Moncousu, F-44035, Nantes, France aut Baum R. J.W. Goethe University Hospital, Theodor-Stern-Kai 7, D-6000, Frankfurt/Main 70, Germany aut Lehur P. Centre René Gauducheau and INSERM Research Unit 211, Quai Moncousu, F-44035, Nantes, France aut Liehn J. Institut J. Godinot, B.P. 171, F-51056, Reims, France aut Perkins A. Queen's Medical Centre, University Hospital, NG7 2UH, Nottingham, UK aut Bares R. Department of Nuclear Medicine, Technical University, Pauwelsstrasse 30, D-5100, Aachen, Germany aut Bourguet P. Centre E. Marquis, 2 rue H. Le Guilloux, F-35033, Rennes, France aut Herry J. Centre E. Marquis, 2 rue H. Le Guilloux, F-35033, Rennes, France aut Saccavini J. CIS Bioindustrie, B.P. 32, F-91191, Gif sur Yvette, France aut Chatal J. Centre René Gauducheau and INSERM Research Unit 211, Quai Moncousu, F-44035, Nantes, France aut European Journal of Nuclear Medicine Springer-Verlag 17/5(1990-05-01), 223-229 0340-6997 17:5<223 1990 17 259 https://doi.org/10.1007/BF00812361 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00812361 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chetanneau A. Centre René Gauducheau and INSERM Research Unit 211, Quai Moncousu, F-44035, Nantes, France aut NATIONALLICENCE 700 1- Baum R. J.W. Goethe University Hospital, Theodor-Stern-Kai 7, D-6000, Frankfurt/Main 70, Germany aut NATIONALLICENCE 700 1- Lehur P. Centre René Gauducheau and INSERM Research Unit 211, Quai Moncousu, F-44035, Nantes, France aut NATIONALLICENCE 700 1- Liehn J. Institut J. Godinot, B.P. 171, F-51056, Reims, France aut NATIONALLICENCE 700 1- Perkins A. Queen's Medical Centre, University Hospital, NG7 2UH, Nottingham, UK aut NATIONALLICENCE 700 1- Bares R. Department of Nuclear Medicine, Technical University, Pauwelsstrasse 30, D-5100, Aachen, Germany aut NATIONALLICENCE 700 1- Bourguet P. Centre E. Marquis, 2 rue H. Le Guilloux, F-35033, Rennes, France aut NATIONALLICENCE 700 1- Herry J. Centre E. Marquis, 2 rue H. Le Guilloux, F-35033, Rennes, France aut NATIONALLICENCE 700 1- Saccavini J. CIS Bioindustrie, B.P. 32, F-91191, Gif sur Yvette, France aut NATIONALLICENCE 700 1- Chatal J. Centre René Gauducheau and INSERM Research Unit 211, Quai Moncousu, F-44035, Nantes, France aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 17/5(1990-05-01), 223-229 0340-6997 17:5<223 1990 17 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer