caa a22 4500 465785409 CHVBK 20180323112007.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00812362 doi (NATIONALLICENCE)springer-10.1007/BF00812362 Experimental complete ureteric occlusion in sheep: radionuclide renography and histopathologic findings [Elektronische Daten] [Abdelhamid Elgazzar, Riad Bahar, Fikri Abu-Zidan, Issam Francis, Mohammed Sabha, Kypros Kouris, Maha Awdeh, Hussein Abdel-Dayem, Keith Britton, Torgny Nilsson] Complete ureteric occlusion produces various pathophysiological changes that can be monitored externally by technetium 99m diethylenetriamine penta-acetic acid (99mTc-DTPA) diuretic renography (RDR). Being a dynamic imaging study, it reflects the function of the kidneys and the urodynamics of the urinary tract. The aim of this study was to correlate the changes in parameters of RDR with the histological changes before and after the release of complete ureteric occlusion. In 9 sheep, RDR studies were performed serially after various periods of complete ureteric occlusion (up to 7 weeks) and after release of the occlusion (up to 5 weeks). The histological changes were correlated with changes in RDR. The progressive decrease in renal flow seen on renal images and flow time-activity curves (TACs) was explained by the development of endarteritis and thrombosis of small renal arteries. The progressive decrease in the renal uptake as indicated by the percentage renal uptake and the extraction slope of TAC is related to the progressive damage to the renal parenchyma, initially affecting the collecting ducts and tubules, with increasing interstitial fibrosis in the later stages. Obstruction for 3 weeks or less was associated with moderate damage to the parenchyma from which recovery was possible. Obstruction for 7 weeks was associated with marked damage without chance of recovery. The RDR is a non-invasive technique that can be used to monitor kidney damage after various periods of complete ureteric occlusion and to predict the outcome of surgery before the release of occlusion. Springer-Verlag, 1990 Experimental ureteric obstruction nationallicence Radio-nuclide diuretic renography nationallicence Obstructive uropathy nationallicence Elgazzar Abdelhamid Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut Bahar Riad Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut Abu-Zidan Fikri Department of Surgery, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut Francis Issam Department of Pathology, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut Sabha Mohammed Department of Surgery, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut Kouris Kypros Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut Awdeh Maha Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut Abdel-Dayem Hussein Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut Britton Keith St. Bartholomew's Hospital, London, UK aut Nilsson Torgny Department of Surgery, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut European Journal of Nuclear Medicine Springer-Verlag 17/5(1990-05-01), 230-233 0340-6997 17:5<230 1990 17 259 https://doi.org/10.1007/BF00812362 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00812362 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elgazzar Abdelhamid Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut NATIONALLICENCE 700 1- Bahar Riad Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut NATIONALLICENCE 700 1- Abu-Zidan Fikri Department of Surgery, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut NATIONALLICENCE 700 1- Francis Issam Department of Pathology, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut NATIONALLICENCE 700 1- Sabha Mohammed Department of Surgery, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut NATIONALLICENCE 700 1- Kouris Kypros Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut NATIONALLICENCE 700 1- Awdeh Maha Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut NATIONALLICENCE 700 1- Abdel-Dayem Hussein Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut NATIONALLICENCE 700 1- Britton Keith St. Bartholomew's Hospital, London, UK aut NATIONALLICENCE 700 1- Nilsson Torgny Department of Surgery, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 17/5(1990-05-01), 230-233 0340-6997 17:5<230 1990 17 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer