caa a22 4500 465785425 CHVBK 20180323112007.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF01566007 doi (NATIONALLICENCE)springer-10.1007/BF01566007 "Luxury perfusion” with99mTc-HMPAO and123I-IMP SPECT imaging during the subacute phase of stroke [Elektronische Daten] [Jean-Luc Moretti, Gilles Defer, Luc Cinotti, Pierre Cesaro, Jean-Denis Degos, Nadine Vigneron, Dominique Ducassou, B. Holman] To compare the merits of123I-isopropyl-iodoam-phetamine (123I-IMP) and99mTc-HMPAO in showing abnormal brain uptake distribution during cerebral ischemia, we studied ten patients during the subacute phase of their stroke, a period where metabolism and blood flow are frequently uncoupled. SPECT imaging was performed using both radiopharmaceuticals in the 10 patients from 48 h to 4 weeks after onset of symptoms. Two patients out of the 10 had similar defects with123I-IMP and99mTc-HMPAO SPECT, the location of the defects corresponding to the area of infarction observed on CT. Six patients had normal99mTc-HMPAO SPECT and abnormal123I-IMP SPECT with defects in the area of infarction shown by CT. The remaining 2 patients had hyperactive abnormalities on99mTc-HMPAO in areas corresponding to defects on the123I-IMP images. Two of the patients with SPECT mismatches were studied again more than 1 month after onset. On reexamination,99mTc-HMPAO SPECT which was previously normal or hyperactive became hypoactive with a focal area of decreased activity corresponding to the defect on123I-IMP. Crossed cerebellar diaschisis was found in 7 patients with99mTc-HMPAO and was absent for both123I-IMP and99mTc-HMPAO in 3. We suggest that SPECT with99mTc-HMPAO could show transient hyperemia not demonstrated by123I-IMP whereas in some cases cerebral infarction would be more difficult to demonstrate with99mTc-HMPAO than with123I-IMP. SPECT with both tracers is recommended to follow the evolution of strokes in terms of regional cerebral blood flow and tissue metabolism. Springer-Verlag, 1990 99mTc-HMPAO nationallicence 123I-IMP SPECT nationallicence Stroke nationallicence luxury perfusion nationallicence Moretti Jean-Luc Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut Defer Gilles Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut Cinotti Luc Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut Cesaro Pierre Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut Degos Jean-Denis Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut Vigneron Nadine Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut Ducassou Dominique Bordeaux University, Bordeaux, France aut Holman B. Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA aut European Journal of Nuclear Medicine Springer-Verlag 16/1(1990-01-01), 17-22 0340-6997 16:1<17 1990 16 259 https://doi.org/10.1007/BF01566007 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01566007 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moretti Jean-Luc Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut NATIONALLICENCE 700 1- Defer Gilles Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut NATIONALLICENCE 700 1- Cinotti Luc Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut NATIONALLICENCE 700 1- Cesaro Pierre Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut NATIONALLICENCE 700 1- Degos Jean-Denis Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut NATIONALLICENCE 700 1- Vigneron Nadine Department of Medical Neurosciences, C.H.U. Henri Mondor, Créteil, France aut NATIONALLICENCE 700 1- Ducassou Dominique Bordeaux University, Bordeaux, France aut NATIONALLICENCE 700 1- Holman B. Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/1(1990-01-01), 17-22 0340-6997 16:1<17 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer