caa a22 4500 46578545X CHVBK 20180323112007.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF01566009 doi (NATIONALLICENCE)springer-10.1007/BF01566009 A kinetic model for99mTc-DMSA in the rat [Elektronische Daten] [Daniel Maneval, David D'Argenio, Walter Wolf] A pharmacokinetic model was developed for the renal imaging agent9mTc-DMSA in anesthetized rats, which incorporated data from serial measurements of blood and urine simultaneously with dynamic images obtained over an 8-h period. Animals which received a 10 mg/kg dose of unlabeled DMSA immediately before99mTc-DMSA injection had a significantly reduced kidney accumulation and greater urinary elimination of99mTc than animals which received the radiopharmaceutical alone. The kidney clearance was also significantly lower in rats receiving unlabeled DMSA, but no significant difference was determined between the urine clearance estimates of the two animal groups. Because the increase in the amount eliminated in the urine was not coupled with a significant change in urine clearance, it would appear that unlabeled DMSA saturated the kidney uptake mechanism(s) of99mTc-DMSA without modifying the urinary clearance process. This interpretation is consistent with the hypothesis that renal handling of99m'Tc-DMSA is governed by both glomerular filtration and peritubular capillary uptake. The simultaneous acquisition of blood, urine and non invasive image data allows for a comprehensive and informative model of the physiological disposition of99mTc-DMSA. Springer-Verlag, 1990 Dimercaptosuccinic acid nationallicence DMSA nationallicence Technetium-99m nationallicence Renal function nationallicence Radiopharmacokinetics nationallicence Maneval Daniel Department of Biomedical Engineering, University of Southern California, USA aut D'Argenio David Department of Biomedical Engineering, University of Southern California, USA aut Wolf Walter Radiopharmacy Program, University of Southern California, USA aut European Journal of Nuclear Medicine Springer-Verlag 16/1(1990-01-01), 29-34 0340-6997 16:1<29 1990 16 259 https://doi.org/10.1007/BF01566009 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01566009 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maneval Daniel Department of Biomedical Engineering, University of Southern California, USA aut NATIONALLICENCE 700 1- D'Argenio David Department of Biomedical Engineering, University of Southern California, USA aut NATIONALLICENCE 700 1- Wolf Walter Radiopharmacy Program, University of Southern California, USA aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/1(1990-01-01), 29-34 0340-6997 16:1<29 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer