caa a22 4500 465785484 CHVBK 20180323112007.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF01566004 doi (NATIONALLICENCE)springer-10.1007/BF01566004 Methoxyisobutylisonitrile (MIBI) Tc 99m SPECT to establish a correlate to coronary flow reserve, the perfusion reserve, from global and regional myocardial uptake after exercise and rest [Elektronische Daten] [Udalrich Buell, Hans-Jürgen Kaiser, Frank Dupont, Rainer Uebis, Eduard Kleinhans, Peter Hanrath] With99mTc-MIBI SPECT and a 4 h exercise (E; 150 MBq iv) and rest (R; 800 MBq iv) protocol global and regional left ventricular (LV) myocardial uptake was determined in 70 patients with angiographicall, confirmed coronary heart disease (CHD) and in 10 controls. The aim was to establish an E/R ratio as a correlate to coronary vascular reserve, representing perfusion reserve (PR). E/R ratios, obtained from total LV myocardium or from normal or impaired regions, were > 1.19 under all conditions, indicating the presence of higher flow during exercise than at rest (even in areas of low flow). Global PR separated (P<0.01) controls (1.63±0.21; mean ± SD) from severely diseased patients (1.29 ±0.14 in 2- or 3-vessel disease) only. Improved differential diagnosis was gained from calibrating the regional E/R ratio to regional differences (E minus R) of uptake. For the left ventricle regional PRs (RPR) for 25 ROIs of the target, framing the myocardium, were determined RPR at the regional maximum of99mTc-MIBI uptake was similar in both controls (1.66) and patients (1.63), indicating a high probability of meeting some areas with functionally normal perfusion in patients with CHD. RPR allowed sufficient separation (P<0.025) concerning the degree of coronary artery stenosis (RPR in occlusion, 0.26; stenosis >75%, 0.39; <75%, 0.56). In controls, the overall value for RPR was 1.14+0.28 (P< 0.001). LV global PR and RPR were useful in separating patients with CHD vs controls and in classifying the severity of vascular stenosis. Springer-Verlag, 1990 Myocardial SPECT nationallicence 99mTc-MIBI nationallicence LV Perfusion reserve nationallicence Coronary heart disease nationallicence Buell Udalrich Department of Nuclear Medicine, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut Kaiser Hans-Jürgen Department of Nuclear Medicine, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut Dupont Frank Department of Nuclear Medicine, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut Uebis Rainer Department of Internal Medicine I, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut Kleinhans Eduard Department of Nuclear Medicine, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut Hanrath Peter Department of Internal Medicine I, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut European Journal of Nuclear Medicine Springer-Verlag 16/1(1990-01-01), 3-9 0340-6997 16:1<3 1990 16 259 https://doi.org/10.1007/BF01566004 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01566004 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Buell Udalrich Department of Nuclear Medicine, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut NATIONALLICENCE 700 1- Kaiser Hans-Jürgen Department of Nuclear Medicine, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut NATIONALLICENCE 700 1- Dupont Frank Department of Nuclear Medicine, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut NATIONALLICENCE 700 1- Uebis Rainer Department of Internal Medicine I, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut NATIONALLICENCE 700 1- Kleinhans Eduard Department of Nuclear Medicine, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut NATIONALLICENCE 700 1- Hanrath Peter Department of Internal Medicine I, Technical University of Aachen, Klinikum, Pauwelsstrasse 30, D-5100, Aachen, Germany aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/1(1990-01-01), 3-9 0340-6997 16:1<3 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer