caa a22 4500 465785530 CHVBK 20180323112008.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF01566010 doi (NATIONALLICENCE)springer-10.1007/BF01566010 Low levels of serum thyroglobulin after withdrawal of thyroid suppression therapy in the follow up of differentiated thyroid carcinoma [Elektronische Daten] [A. Brendel, B. Lambert, M. Guyot, R. Jeandot, H. Dubourg, P. Roger, S. Wynchauk, G. Manciet, G. Lefort] We evaluated the reliability of very low serum thyroglobulin (Tg) levels (< 3 ng/ml) obtained after withdrawal of thyroid suppression therapy in 224 patients without anti-Tg antibodies, who had undergone total thyroidectomy (125 patients) or thyroidectomy followed by 1 or more courses of131I therapy (99 patients), by performing whole body scans after a therapeutic course of131I given at the same time of Tg measurement. In 79 patients (35%) a positive scan, associated with a very low level of Tg, was noted. The 1311 uptake was limited to the thyroid bed in 60 patients, but metastases were demonstrated in 19 patients (8.5%). These results are mainly explained by the much improved performance of scintigraphy after administration of therapeutic doses of131I. In the majority of patients, especially those whose131I uptake was limited to the thyroid bed, further scans were negative. Therefore, in these cases, negative Tg values can generally be considered an early indication of satisfactory evolution. However, in 8.5% of all cases, very low Tg levels were associated with metastases. Thus the follow up of thyroid cancer should not rely only upon Tg determination, even after suppression therapy withdrawal. Springer-Verlag, 1990 Thyroid carcinoma nationallicence Thyroglobulin nationallicence 131I scintigraphy nationallicence Brendel A. Hôpital Univ. Pellegrin et Unité de traitements radio-actifs de l'Hôpital St André, F-33076, Bordeaux, France aut Lambert B. Hôpital Univ. Pellegrin et Unité de traitements radio-actifs de l'Hôpital St André, F-33076, Bordeaux, France aut Guyot M. Hôpital Univ. Pellegrin et Unité de traitements radio-actifs de l'Hôpital St André, F-33076, Bordeaux, France aut Jeandot R. Hôpital Univ. Pellegrin et Unité de traitements radio-actifs de l'Hôpital St André, F-33076, Bordeaux, France aut Dubourg H. Hôpital Univ. Pellegrin et Unité de traitements radio-actifs de l'Hôpital St André, F-33076, Bordeaux, France aut Roger P. Départements d'endocrinologie, Université de Bordeaux, Bordeaux, France aut Wynchauk S. Research Institute for Medical Biophysics of the South African Medical Research Council, P.O. Box 70, 7505, Tygerberg, South Africa aut Manciet G. Départements d'endocrinologie, Université de Bordeaux, Bordeaux, France aut Lefort G. Départements d'endocrinologie, Université de Bordeaux, Bordeaux, France aut European Journal of Nuclear Medicine Springer-Verlag 16/1(1990-01-01), 35-38 0340-6997 16:1<35 1990 16 259 https://doi.org/10.1007/BF01566010 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01566010 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brendel A. Hôpital Univ. Pellegrin et Unité de traitements radio-actifs de l'Hôpital St André, F-33076, Bordeaux, France aut NATIONALLICENCE 700 1- Lambert B. Hôpital Univ. Pellegrin et Unité de traitements radio-actifs de l'Hôpital St André, F-33076, Bordeaux, France aut NATIONALLICENCE 700 1- Guyot M. Hôpital Univ. Pellegrin et Unité de traitements radio-actifs de l'Hôpital St André, F-33076, Bordeaux, France aut NATIONALLICENCE 700 1- Jeandot R. Hôpital Univ. Pellegrin et Unité de traitements radio-actifs de l'Hôpital St André, F-33076, Bordeaux, France aut NATIONALLICENCE 700 1- Dubourg H. Hôpital Univ. Pellegrin et Unité de traitements radio-actifs de l'Hôpital St André, F-33076, Bordeaux, France aut NATIONALLICENCE 700 1- Roger P. Départements d'endocrinologie, Université de Bordeaux, Bordeaux, France aut NATIONALLICENCE 700 1- Wynchauk S. Research Institute for Medical Biophysics of the South African Medical Research Council, P.O. Box 70, 7505, Tygerberg, South Africa aut NATIONALLICENCE 700 1- Manciet G. Départements d'endocrinologie, Université de Bordeaux, Bordeaux, France aut NATIONALLICENCE 700 1- Lefort G. Départements d'endocrinologie, Université de Bordeaux, Bordeaux, France aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/1(1990-01-01), 35-38 0340-6997 16:1<35 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer