caa a22 4500 465785638 CHVBK 20180323112008.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF01280252 doi (NATIONALLICENCE)springer-10.1007/BF01280252 Evaluation of primary lung carcinoma using technetium 99m-hexamethylpropylene amine oxime: preliminary clinical experience [Elektronische Daten] [Motoo Oshima, Kengo Itoh, Shunji Okae, Masanori Tadokoro, Yukihiro Kodama, Sadayuki Sakuma] 99mTc-labelled hexamethylpropylene amine oxime (HMPAO) is a lipophilic compound with a neutral charge which reflects tumor blood flow and has been previously investigated to estimate brain blood flow. In this study, we attempted to use99mTc-HMPAO for the evaluation of 18 patients with histologically proven primary lung carcinoma. The eight surgical specimens revealed that viable carcinoma cells were present when the99mTc-HMPAO accumulated in the tumor, however, extensive tumor necrosis was observed when defective or ring like uptake was seen in the tumor. Qualitative study revealed that when perfusion defects were observed corresponding to the tumor, the possibility of squamous cell carcinoma or large cell carcinoma was high instead of adenocarcinoma. Quantitative analysis revealed that the uptake ratio was statistically different between adenocarcinoma (1.6±0.1) and squamous cell carcinoma (1.2±0.4) (P<0.05), between squamous cell carcinoma and large cell carcinoma (0.9±0.1) (P<0.05), and also between adenocarcinoma and large cell carcinoma (P<0.01). In conclusion,99mTc-HMPAO may be useful for the evaluation of patients with primary lung carcinoma. Springer-Verlag, 1990 Technetium 99m-HMPAO nationallicence Primary lung carcinoma nationallicence Necrotic nationallicence Viable nationallicence Oshima Motoo Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut Itoh Kengo Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut Okae Shunji Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut Tadokoro Masanori Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut Kodama Yukihiro Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut Sakuma Sadayuki Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut European Journal of Nuclear Medicine Springer-Verlag 16/12(1990-12-01), 859-864 0340-6997 16:12<859 1990 16 259 https://doi.org/10.1007/BF01280252 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01280252 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oshima Motoo Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut NATIONALLICENCE 700 1- Itoh Kengo Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut NATIONALLICENCE 700 1- Okae Shunji Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut NATIONALLICENCE 700 1- Tadokoro Masanori Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut NATIONALLICENCE 700 1- Kodama Yukihiro Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut NATIONALLICENCE 700 1- Sakuma Sadayuki Department of Radiology, Nagoya University School of Medicine, 466, Nagoya, Showaku Nagoya, Japan aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/12(1990-12-01), 859-864 0340-6997 16:12<859 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer