caa a22 4500 465785662 CHVBK 20180323112008.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF01146851 doi (NATIONALLICENCE)springer-10.1007/BF01146851 Ligandin binding phthalein complexone complex of technetium for hepatic function studies [Elektronische Daten] [K. Horiuchi, H. Saji, Y. Arano, A. Yokoyama] In our pursuit for liver functional diagnosis, development of bifunctional radiopharmaceutical containing iminodiacetic acid (IDA), as the technetium chelating site along with phthalein or fluorescein structure, the skeleton of BSP and Rose Bengal, long used for the assessment of liver function is considered. Among the various PC, PPC, TPC and calcein IDA derivatives commercially available,99mTc-PC (PC: 3,3′-bis(N, N-dicarboxymethylaminomethyl)o-cresolphthalein) showed the highest hepatobiliary excretion. The functionality of the various technetium labeled phthalein and fluorescein IDA derivatives was evaluated by competitive BSP binding studies and by comparative binding with the hepatocyte specific protein, ligandin. Springer-Verlag, 1990 99mTc-Hepatobiliary agent nationallicence Liver functional studies nationallicence Iminodiacetic derivative of phthalein nationallicence Ligandin nationallicence Horiuchi K. Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences and School of Medicine, Kyoto University, 606, Sakyo-ku, Kyoto, Japan aut Saji H. Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences and School of Medicine, Kyoto University, 606, Sakyo-ku, Kyoto, Japan aut Arano Y. Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences and School of Medicine, Kyoto University, 606, Sakyo-ku, Kyoto, Japan aut Yokoyama A. Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences and School of Medicine, Kyoto University, 606, Sakyo-ku, Kyoto, Japan aut European Journal of Nuclear Medicine Springer-Verlag 16/3(1990-03-01), 137-142 0340-6997 16:3<137 1990 16 259 https://doi.org/10.1007/BF01146851 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01146851 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Horiuchi K. Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences and School of Medicine, Kyoto University, 606, Sakyo-ku, Kyoto, Japan aut NATIONALLICENCE 700 1- Saji H. Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences and School of Medicine, Kyoto University, 606, Sakyo-ku, Kyoto, Japan aut NATIONALLICENCE 700 1- Arano Y. Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences and School of Medicine, Kyoto University, 606, Sakyo-ku, Kyoto, Japan aut NATIONALLICENCE 700 1- Yokoyama A. Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences and School of Medicine, Kyoto University, 606, Sakyo-ku, Kyoto, Japan aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/3(1990-03-01), 137-142 0340-6997 16:3<137 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer