caa a22 4500 465785700 CHVBK 20180323112008.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF01146853 doi (NATIONALLICENCE)springer-10.1007/BF01146853 Clinical experience with intra lymphatic administration of111In-labelled monoclonal antibody PAY 276 for the detection of pelvic nodal metastases in prostatic carcinoma [Elektronische Daten] [Hani Abdel-Nabi, Judith Ortman-Nabi, William See, John Lee, Robert Ireton, Michael Boileau, Michael Unger, Craig Halverson] The ability of111In-PAY 276 (anti prostatic acid phosphatase antibody) in detecting pelvic lymph node metastasis following bipedal intra lymphatic administration was studied in five patients with carcinoma of the prostate. The labeled antibody was injected directly into the lymphatics of each foot. Planar and tomographic images radioactivity content of lymph nodes resected during staging pelvic lymphadenectomy were compared to the histologic and immunoperoxidase findings. Radioactivity in pelvic lymph nodes was prominently seen within 20 min of injection and was present 16 days later. Persistent accumulation of tracer in the lymphatics of the lower extremities was also observed in all patients 16 days post injection. Radioactivity counts in tumor-free lymph nodes were higher than in tumored lymph nodes resected. Our results demonstrate that intra lymphatic administration of111In-labeled PAY 276 monoclonal antibody has major technical limitations, and that further research directed at the causes of tracer accumulation in the lymphatics and tumor-free lymph nodes is required. Springer-Verlag, 1990 Anti prostatic acid phosphatase nationallicence Monoclonal antibody nationallicence Intra lymphatic nationallicence PAY 276 nationallicence 111In nationallicence Abdel-Nabi Hani Department of Nuclear Medicine,Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut Ortman-Nabi Judith Department of Nuclear Medicine,Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut See William Urology, Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut Lee John Radiology, Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut Ireton Robert Urology, Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut Boileau Michael Urology, Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut Unger Michael Hybritech Inc., San Diego, California, USA aut Halverson Craig Hybritech Inc., San Diego, California, USA aut European Journal of Nuclear Medicine Springer-Verlag 16/3(1990-03-01), 149-156 0340-6997 16:3<149 1990 16 259 https://doi.org/10.1007/BF01146853 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01146853 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abdel-Nabi Hani Department of Nuclear Medicine,Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut NATIONALLICENCE 700 1- Ortman-Nabi Judith Department of Nuclear Medicine,Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut NATIONALLICENCE 700 1- See William Urology, Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut NATIONALLICENCE 700 1- Lee John Radiology, Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut NATIONALLICENCE 700 1- Ireton Robert Urology, Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut NATIONALLICENCE 700 1- Boileau Michael Urology, Veterans Administration Medical Center, University of Washington, Seattle Washington, USA aut NATIONALLICENCE 700 1- Unger Michael Hybritech Inc., San Diego, California, USA aut NATIONALLICENCE 700 1- Halverson Craig Hybritech Inc., San Diego, California, USA aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/3(1990-03-01), 149-156 0340-6997 16:3<149 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer