caa a22 4500 465785891 CHVBK 20180323112009.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00842779 doi (NATIONALLICENCE)springer-10.1007/BF00842779 Reproducibility of cerebral glucose utilization measured by PET and the [18F]-2-fluoro-2-deoxy-d-glucose method in resting, healthy human subjects [Elektronische Daten] [Pierre Maquet, Dominique Dive, Eric Salmon, Remy von Frenckel, Georges Franck] The stability of cerebral glucose utilization was examined in nine right-handed, healthy men (age, 24.88±2.93 years) using positron emission tomography (PET) and the [18F]-fluorodeoxyglucose (FDG) method. Each study was run twice at intervals of 1-12 weeks with the subject at rest. The average cerebral metabolic rate for glucose (CMRGlu) was 5.40±0.71 mg/100 g per min (coefficient of variance, 13.08). The average intraindividual variation of CMRGlu was 7.91%±15.46% (P=0.13). Metabolic indices (MI: regional/mean cortical CMRGlu) were used to determine the regional cerebral metabolic distribution. The interindividual (coefficient of variance, 7.13) and intraindividual variabilities (average variation, −0.12%±8.76%) of MI were smaller than those of metabolic rates. No reproducible significant asymmetry was observed. The FDG method used with subjects at rest thus yields low intraindividual variability of both cerebral glucose consumption and regional metabolic distribution, even at an interval of several weeks. Cerebral glucose utilization measured under such conditions may act as a reliable reference for determination of the influences of physiological (activation), pharmacological or pathological processes on cerebral glucose metabolism. Springer-Verlag 1990, 1990 Cerebral glucose utilization nationallicence Interindividual and intraindividual variability nationallicence Resting state nationallicence Positron emission tomography nationallicence [18F]-fluorodeoxyglucose nationallicence FDG : [18F]-fluorodeoxyglucose nationallicence CMRGlu : cerebral metabolic rates for glucose nationallicence MI : metabolic indices nationallicence EEG : electroencephalogram nationallicence FWHM : full width at half maximum nationallicence Maquet Pierre Department of Neurology and Cyclotron Research Center, University of Liège, Sart Tilman, B-4000, Liège, Belgium aut Dive Dominique Department of Neurology and Cyclotron Research Center, University of Liège, Sart Tilman, B-4000, Liège, Belgium aut Salmon Eric Department of Neurology and Cyclotron Research Center, University of Liège, Sart Tilman, B-4000, Liège, Belgium aut von Frenckel Remy Department of Neurology and Cyclotron Research Center, University of Liège, Sart Tilman, B-4000, Liège, Belgium aut Franck Georges Department of Neurology and Cyclotron Research Center, University of Liège, Sart Tilman, B-4000, Liège, Belgium aut European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 267-273 0340-6997 16:4-6<267 1990 16 259 https://doi.org/10.1007/BF00842779 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00842779 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maquet Pierre Department of Neurology and Cyclotron Research Center, University of Liège, Sart Tilman, B-4000, Liège, Belgium aut NATIONALLICENCE 700 1- Dive Dominique Department of Neurology and Cyclotron Research Center, University of Liège, Sart Tilman, B-4000, Liège, Belgium aut NATIONALLICENCE 700 1- Salmon Eric Department of Neurology and Cyclotron Research Center, University of Liège, Sart Tilman, B-4000, Liège, Belgium aut NATIONALLICENCE 700 1- von Frenckel Remy Department of Neurology and Cyclotron Research Center, University of Liège, Sart Tilman, B-4000, Liège, Belgium aut NATIONALLICENCE 700 1- Franck Georges Department of Neurology and Cyclotron Research Center, University of Liège, Sart Tilman, B-4000, Liège, Belgium aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 267-273 0340-6997 16:4-6<267 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer