caa a22 4500 465785921 CHVBK 20180323112009.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00842788 doi (NATIONALLICENCE)springer-10.1007/BF00842788 The diagnostic and therapeutic utility of radioiodinated metaiodobenzy1guanidine (MIBG) [Elektronische Daten] 5 years of experience [Luigi Troncone, Vittoria Rufini, Paolo Montemaggi, Francesco Danza, Anna Lasorella, Renato Mastrangelo] The authors' experience of more than 5 years in the diagnostic and therapeutic use of radioiodinated MIBG in neural crest tumors is reported.123I/131I-MIBG scintigraphhy was performed in 158 patients: 75 suspected (24 proven) pheochromocytomas (pheos), 43 neuroblastomas (NB), 20 medullary thyroid carcinomas (MTC), 6 ganglioneuromas, 5 carcinoids and 1 insulinoma. Eight cases of tumors not originating from the neural crest were also investigated. The diagnostic sensitivity of the method was above 90% both in pheos and NB (primary tumors and bone metastases). The examination was less effective in localizing MTC (sensitivity=64.4% in primary or residual/recurrent tumors). The scintigraphie outcome was negative in ganglioneuromas, carcinoids and insulinoma. Specificity was very high (> 95%), and no false positive results were found in tumors not deriving from the neural crest. 131I-MIBG treatment was administered to four patients with malignant pheo, nine with NB and four with MTC. Therapy resulted in a complete response in one pheo, two NB and one MTC treated after surgery or at diagnosis (one NB), it gave partial response and prolonged remission in five advanced cases (one pheo, two NB and two MTC); it resulted in temporary stabilization of the disease in one pheo and two NBs, it was ineffective in four cases. Springer-Verlag, 1990 Radioiodinated metaiodobenzylguanidine nationallicence Neural crest tumors nationallicence Diagnosis nationallicence Therapy nationallicence Troncone Luigi Department of Nuclear Medicine of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut Rufini Vittoria Department of Nuclear Medicine of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut Montemaggi Paolo Department of Radiology of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut Danza Francesco Department of Radiology of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut Lasorella Anna Department of Pediatrics of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut Mastrangelo Renato Department of Pediatrics of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 325-335 0340-6997 16:4-6<325 1990 16 259 https://doi.org/10.1007/BF00842788 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00842788 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Troncone Luigi Department of Nuclear Medicine of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut NATIONALLICENCE 700 1- Rufini Vittoria Department of Nuclear Medicine of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut NATIONALLICENCE 700 1- Montemaggi Paolo Department of Radiology of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut NATIONALLICENCE 700 1- Danza Francesco Department of Radiology of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut NATIONALLICENCE 700 1- Lasorella Anna Department of Pediatrics of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut NATIONALLICENCE 700 1- Mastrangelo Renato Department of Pediatrics of Cathoiic University of the Sacred Heart, I-00168, Rome, Italy aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 325-335 0340-6997 16:4-6<325 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer