caa a22 4500 465785956 CHVBK 20180323112009.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00842780 doi (NATIONALLICENCE)springer-10.1007/BF00842780 Quantitative analysis of99mTc-HMPAO kinetics in epilepsy [Elektronische Daten] [Jyrki Kuikka, Esko Länsimies, Elia Kuikka] A convection-diffusion model is applied for the determination of cerebral circulation parameters in patients with frontal lobe epilepsy. The method employs99mTc-HMPAO, dynamic brain imaging and SPECT. The model takes into account both the capillary and cell permeabilities of HMPAO. Experiments were performed in 41 patients with epilepsy and 10 patients with out evident cerebrovascular disease. The results indicate that in the inter ictal epileptic foci, cerebral blood flow was reduced (18%±19%), cerebral blood volume was increased (21%±14%), and the capillary permeability of HMPAO in the affected side was on the average 50% of the value in the contralateral side, whereas the reflux from brain tissue to blood was increased. These findings mean that HMPAO diffusion across the blood brain barrier is restricted and HMPAO slackly interacts with the intra cellular component of the inter ictal epileptic foci. Springer-Verlag, 1990 Cerebral blood flow nationallicence Emission tomography nationallicence Epilepsy nationallicence Mathematical modeling nationallicence Permeability nationallicence Kuikka Jyrki Department of Clinical Physiology, , University Central Hospital, Finland aut Länsimies Esko Department of Clinical Physiology, , University Central Hospital, Finland aut Kuikka Elia Department of Clinical Physiology, , University Central Hospital, Finland aut European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 275-283 0340-6997 16:4-6<275 1990 16 259 https://doi.org/10.1007/BF00842780 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00842780 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuikka Jyrki Department of Clinical Physiology, , University Central Hospital, Finland aut NATIONALLICENCE 700 1- Länsimies Esko Department of Clinical Physiology, , University Central Hospital, Finland aut NATIONALLICENCE 700 1- Kuikka Elia Department of Clinical Physiology, , University Central Hospital, Finland aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 275-283 0340-6997 16:4-6<275 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer