caa a22 4500 465785972 CHVBK 20180323112009.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00842776 doi (NATIONALLICENCE)springer-10.1007/BF00842776 In vivo metabolism and kinetics of99mTc-HMPAO [Elektronische Daten] [G. Lucignani, C. Rossetti, P. Ferrario, L. Zecca, M. Gilardi, F. Zito, D. Perani, G. Lenzi, F. Fazio] The cerebral distribution of99mTc-labeled d, l, hexamethyl-propylene-amine-oxime (99mTc-HMPAO) as a function of rCBF and time was examined in rats and in man. The results of this study confirm that99mTc-HMPAO is distributed in brain in proportion to rCBF. However, the rapid systemic breakdown of the tracer in blood results in considerable difficulties in the assessment of the arterial concentration of the parent compound; incomplete extraction of99mTc-HMPAO from blood to brain and significant efflux from brain represent further limitations in the use of this tracer for quantification of rCFB. Despite these limitations99mTc-HMPAO is of potential interest for a qualitative assessment of rCBF in specific clinical conditions. Springer-Verlag, 1990 SPECT nationallicence Brain nationallicence Blood flow nationallicence 99mTc nationallicence Lucignani G. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut Rossetti C. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut Ferrario P. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut Zecca L. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut Gilardi M. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut Zito F. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut Perani D. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut Lenzi G. Dipartimento di Scienze Neurologiche Universita di Roma, Italy aut Fazio F. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 249-255 0340-6997 16:4-6<249 1990 16 259 https://doi.org/10.1007/BF00842776 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00842776 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lucignani G. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut NATIONALLICENCE 700 1- Rossetti C. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut NATIONALLICENCE 700 1- Ferrario P. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut NATIONALLICENCE 700 1- Zecca L. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut NATIONALLICENCE 700 1- Gilardi M. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut NATIONALLICENCE 700 1- Zito F. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut NATIONALLICENCE 700 1- Perani D. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut NATIONALLICENCE 700 1- Lenzi G. Dipartimento di Scienze Neurologiche Universita di Roma, Italy aut NATIONALLICENCE 700 1- Fazio F. ITBA-CNR, Università di Milano, Istituto H.S. Raffaele, Milano, Italy aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 249-255 0340-6997 16:4-6<249 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer