caa a22 4500 465785999 CHVBK 20180323112009.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00842777 doi (NATIONALLICENCE)springer-10.1007/BF00842777 Maps of receptor binding parameters in the human brain — a kinetic analysis of PET measurements [Elektronische Daten] [Gunnar Blomqvist, Stefan Pauli, Lars Farde, Lars Eriksson, Anders Persson, Christer Halldin] A kinetic method is described for the estimation of neuroreceptor density as well as the rate constants for association and dissociation of rapidly equilibrating radioligands. The method is exemplified by positron emission tomographic measurements of the human brain using11C-raclopride, a D 2 dopamine receptor antagonist, and11C-Ro 15-1788, a benzodiazepine receptor antagonist. Using a linear non iterative algorithm, regional binding characteristics were calculated and displayed pixel by pixel in brain maps. Data from repeated experiments on the same subject with different amounts of the unlabeled ligand were utilized. The binding characteristics were determined according to a two step procedure in which the time course of the free radioligand concentration was estimated from a reference region considered to be free of specific receptor binding sites. Alternative methods to determine the concentration of free radioligand are discussed. Springer-Verlag, 1990 Positron emission tomography nationallicence Radioligands nationallicence Brain maps nationallicence Receptor density nationallicence Blomqvist Gunnar Department of Clinical Neurophysiology, Karolinska Institute and Hospital, Stockholm, Sweden aut Pauli Stefan Department of Psychiatry and Psychology, Karolinska Institute and Hospital, Stockholm, Sweden aut Farde Lars Department of Psychiatry and Psychology, Karolinska Institute and Hospital, Stockholm, Sweden aut Eriksson Lars Department of Clinical Neurophysiology, Karolinska Institute and Hospital, Stockholm, Sweden aut Persson Anders Department of Psychiatry and Psychology, Karolinska Institute and Hospital, Stockholm, Sweden aut Halldin Christer Karolinska Pharmacy, Karolinska Institute and Hospital, Stockholm, Sweden aut European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 257-265 0340-6997 16:4-6<257 1990 16 259 https://doi.org/10.1007/BF00842777 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00842777 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blomqvist Gunnar Department of Clinical Neurophysiology, Karolinska Institute and Hospital, Stockholm, Sweden aut NATIONALLICENCE 700 1- Pauli Stefan Department of Psychiatry and Psychology, Karolinska Institute and Hospital, Stockholm, Sweden aut NATIONALLICENCE 700 1- Farde Lars Department of Psychiatry and Psychology, Karolinska Institute and Hospital, Stockholm, Sweden aut NATIONALLICENCE 700 1- Eriksson Lars Department of Clinical Neurophysiology, Karolinska Institute and Hospital, Stockholm, Sweden aut NATIONALLICENCE 700 1- Persson Anders Department of Psychiatry and Psychology, Karolinska Institute and Hospital, Stockholm, Sweden aut NATIONALLICENCE 700 1- Halldin Christer Karolinska Pharmacy, Karolinska Institute and Hospital, Stockholm, Sweden aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 257-265 0340-6997 16:4-6<257 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer