caa a22 4500 465786006 CHVBK 20180323112009.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00842787 doi (NATIONALLICENCE)springer-10.1007/BF00842787 European multicentre study on melanoma immunoscintigraphy by means of99mTc-labelled monoclonal antibody fragments [Elektronische Daten] [Antonio Siccardi, Gian Buraggi, Pier Natali, Gian Scassellati, Giovanna Viale, Soldano Ferrones] A total of 493 melanoma patients were investigated by 20 European nuclear medicine departments by means of the saine99mTc-labelled immunoradiopharmaceutical and the same immunoscintigraphy (ISG) protocol. (i) No chemical or clinical toxicity was detected during or following the studies. (ii) Positive results were obtained in 287/363 (79%) patients (321 carrying known lesions and 42 carrying previously occult lesions): in 231 (80%) of them, 402/402 lesions were imaged, in the remaining 56 ISG-positive patients, 108/204 lesions were imaged; in 76 patients 0/122 lesions were ïmaged. (iii) The fraction of melanoma lesions visualized by ISG was 510/728 (70A%); 605 of these lesions were already documented at the time of the study, and 123 were previously occult. (iv) A total of 218 documented melanoma lesions (30%) were not visualized by ISG in 132 patients: about 70% of the ISG-negative lesions were of small size (less than 2 cm diameter). (v) The melanoma nature of 69/123 previously occult lesions was confirmed by clinical criteria and/or additional investigations in follow-up studies. The results obtained in this study are similar to those obtained in the Italian Multicentre Study which had previously been carried out with 258 melanoma patients. Springer-Verlag, 1990 Immunoscintigraphy nationallicence 99mTc - multicentre study nationallicence Siccardi Antonio Dipartimento di Biologia e Genetica, Università di Milano, via G.B. Viotti 3/5, I-20133, Milano, Italy aut Buraggi Gian Istituto Nazionale Tumori, via Venezian 1, I-20130, Milano, Italy aut Natali Pier Istituto Tumori Regina Elena, viale Regina Elena 291, I-00161, Roma, Italy aut Scassellati Gian Centro Ricerche-SORIN Biomedica, Strada per Crescentino, I-13040, Saiuggia, Italy aut Viale Giovanna Dipartimento di Biologia e Genetica, Università di Milano, via G.B. Viotti 3/5, I-20133, Milano, Italy aut Ferrones Soldano Department of Microbioiogy and Immunology, New York Medical College, 10595, Valhalla, NY, USA aut European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 317-323 0340-6997 16:4-6<317 1990 16 259 https://doi.org/10.1007/BF00842787 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00842787 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Siccardi Antonio Dipartimento di Biologia e Genetica, Università di Milano, via G.B. Viotti 3/5, I-20133, Milano, Italy aut NATIONALLICENCE 700 1- Buraggi Gian Istituto Nazionale Tumori, via Venezian 1, I-20130, Milano, Italy aut NATIONALLICENCE 700 1- Natali Pier Istituto Tumori Regina Elena, viale Regina Elena 291, I-00161, Roma, Italy aut NATIONALLICENCE 700 1- Scassellati Gian Centro Ricerche-SORIN Biomedica, Strada per Crescentino, I-13040, Saiuggia, Italy aut NATIONALLICENCE 700 1- Viale Giovanna Dipartimento di Biologia e Genetica, Università di Milano, via G.B. Viotti 3/5, I-20133, Milano, Italy aut NATIONALLICENCE 700 1- Ferrones Soldano Department of Microbioiogy and Immunology, New York Medical College, 10595, Valhalla, NY, USA aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 317-323 0340-6997 16:4-6<317 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer