caa a22 4500 465786030 CHVBK 20180323112009.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00842769 doi (NATIONALLICENCE)springer-10.1007/BF00842769 The metabolism of 15-p-[123I]-iodophenylpentadecanoic acid in a surgically induced canine model of regional ischemia [Elektronische Daten] [Marck Hudon, Donald Lyster, W. Jamieson, A. Qayumi, Craig Sartori, Hayes Dougan] The purpose of this study was to examine the longitudinal effect of gradual coronary occlusion on regional myocardial metabolism of 15-p-123I-iodophenyl pentadecanoic acid ([123I]IPPA). Adult dogs were imaged using [123I]IPPA and planar gamma imaging. A thoracotomy was performed and an ameroid constrictor of appropriate size permanently positioned on the left anterior descending coronary artery. The dogs were imaged after injection of 3-5 mCi [123I]IPPA at various times over a 2-week period. With imaging on days 7 and 14, the dogs were paced at a rate of 185. Time-activity curves were generated and t1/2 values calculated using monoexponential curve fitting. Results indicate a significant increase in t1/2 between control and 14 days after surgery in the apical wall (29±7 to 53±18 min;P<0.05). Although there was also an increased t1/2 in the lateral wall, this was not significant (27±8 to 78±99 min;P > 0.05). There was no significant change in t/12 in the septal wall (27±9 to 33±8 min;P>0.05). We conclude that [123I]IPPA is a useful indicator of Springer-Verlag, 1990 Cardiac metabolism nationallicence Ischemia nationallicence Coronary artery disease nationallicence Hudon Marck Department of Surgery, Division of Cardiovascular and Thoracic Surgery, University of British Columbia/Vancouver General Hospital, Canada aut Lyster Donald Department of Radiology, Division of Nuclear Medicine, University of British Columbia/Vancouver General Hospital, Canada aut Jamieson W. Department of Surgery, Division of Cardiovascular and Thoracic Surgery, University of British Columbia/Vancouver General Hospital, Canada aut Qayumi A. Department of Surgery, Division of Cardiovascular and Thoracic Surgery, University of British Columbia/Vancouver General Hospital, Canada aut Sartori Craig Department of Radiology, Division of Nuclear Medicine, University of British Columbia/Vancouver General Hospital, Canada aut Dougan Hayes TRIM Group (TRIUMF Radioisotopes for Medicine), University of British Columbia, Vancouver, British Columbia, Canada aut European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 199-204 0340-6997 16:4-6<199 1990 16 259 https://doi.org/10.1007/BF00842769 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00842769 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hudon Marck Department of Surgery, Division of Cardiovascular and Thoracic Surgery, University of British Columbia/Vancouver General Hospital, Canada aut NATIONALLICENCE 700 1- Lyster Donald Department of Radiology, Division of Nuclear Medicine, University of British Columbia/Vancouver General Hospital, Canada aut NATIONALLICENCE 700 1- Jamieson W. Department of Surgery, Division of Cardiovascular and Thoracic Surgery, University of British Columbia/Vancouver General Hospital, Canada aut NATIONALLICENCE 700 1- Qayumi A. Department of Surgery, Division of Cardiovascular and Thoracic Surgery, University of British Columbia/Vancouver General Hospital, Canada aut NATIONALLICENCE 700 1- Sartori Craig Department of Radiology, Division of Nuclear Medicine, University of British Columbia/Vancouver General Hospital, Canada aut NATIONALLICENCE 700 1- Dougan Hayes TRIM Group (TRIUMF Radioisotopes for Medicine), University of British Columbia, Vancouver, British Columbia, Canada aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 199-204 0340-6997 16:4-6<199 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer