caa a22 4500 465786049 CHVBK 20180323112009.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00842774 doi (NATIONALLICENCE)springer-10.1007/BF00842774 Production of carrier-free66Ga and labeling of antimyosin antibody for positron imaging of acute myocardial infarction [Elektronische Daten] [Patrick Goethals, Manuella Coene, Guido Slegers, Dirk Vogelaers, Jan Everaert, Ignace Lemahieu, Francis Colardyn, Guy Heyndrickx] A method for labeling monoclonal antimyosin antibodies with66Ga is described. The radionuclide is a positron emitter (t1/2: 9.4 h) produced by means of the63Cu (4He, n)66Ga reaction. Purification of the66Ga from the copper target is described in detail. Monoclonal antimyosin antibodies are labeled with66Ga at a high yield (99%) by transcomplexation from an acetate buffer with the diethylenetriamine pentaacetic acid (DTPA)-labeled antibody and preliminary evaluated in two dogs for imaging of myocardial necrosis by positron emission tomography. Springer-Verlag, 1990 66Ga production nationallicence Antimyosin monoclonal antibodies nationallicence Myocardial necrosis nationallicence Positron emission tomography (PET) nationallicence Goethals Patrick Institute for Nuclear Sciences, Rijksuniversiteit Gent, Proeftuinstraat 86, B-9000, Gent, Belgium aut Coene Manuella Institute for Nuclear Sciences, Rijksuniversiteit Gent, Proeftuinstraat 86, B-9000, Gent, Belgium aut Slegers Guido Faculty of Pharmaceutical Sciences, Laboratory of Analytical Chemistry, Gent, Belgium aut Vogelaers Dirk Intensive Care Unit, University Hospital, Gent, Belgium aut Everaert Jan Intensive Care Unit, University Hospital, Gent, Belgium aut Lemahieu Ignace Laboratory for Electronics and Metrology, Gent, Belgium aut Colardyn Francis Intensive Care Unit, University Hospital, Gent, Belgium aut Heyndrickx Guy Department of Physiology, State University Gent, Gent, Belgium aut European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 237-240 0340-6997 16:4-6<237 1990 16 259 https://doi.org/10.1007/BF00842774 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00842774 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goethals Patrick Institute for Nuclear Sciences, Rijksuniversiteit Gent, Proeftuinstraat 86, B-9000, Gent, Belgium aut NATIONALLICENCE 700 1- Coene Manuella Institute for Nuclear Sciences, Rijksuniversiteit Gent, Proeftuinstraat 86, B-9000, Gent, Belgium aut NATIONALLICENCE 700 1- Slegers Guido Faculty of Pharmaceutical Sciences, Laboratory of Analytical Chemistry, Gent, Belgium aut NATIONALLICENCE 700 1- Vogelaers Dirk Intensive Care Unit, University Hospital, Gent, Belgium aut NATIONALLICENCE 700 1- Everaert Jan Intensive Care Unit, University Hospital, Gent, Belgium aut NATIONALLICENCE 700 1- Lemahieu Ignace Laboratory for Electronics and Metrology, Gent, Belgium aut NATIONALLICENCE 700 1- Colardyn Francis Intensive Care Unit, University Hospital, Gent, Belgium aut NATIONALLICENCE 700 1- Heyndrickx Guy Department of Physiology, State University Gent, Gent, Belgium aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 237-240 0340-6997 16:4-6<237 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer