caa a22 4500 465786057 CHVBK 20180323112009.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00842793 doi (NATIONALLICENCE)springer-10.1007/BF00842793 Accurate quantification of131I distribution by gamma camera imaging [Elektronische Daten] [Alan Green, Sarah Dewhurst, Richard Begent, Kenneth Bagshawe, Simon Riggs] The development of targeted therapy requires that the concentration of the therapeutic agent can be estimated in target and normal tissues. Single photon emission tomography (SPET), with and without scatter correction, and planar imaging using131I have been compared to develop a method for investigation of targeted therapy. Compton scatter was investigated using line spread functions in air and water, these data were used to set a second peak, adjacent to the photopeak, for scatter correction. The system was calibrated with an eliptical phantom containing sources in background activity of various intensities. Scatter corrected reconstructions gave accurate estimates of activity in the sources regardless of background activity. For planar scanning and SPET without scatter correction there was an overestimate of activity in the source of 290% and 40% respectively. The validity of this method was confirmed in patients by comparing activity in the cardiac ventricles measured by SPET with scatter correction with that in a simultaneous blood sample. A coefficient of correlation of 0.955 was achieved with 25 data points. SPET with scatter correction was compared with planar imaging in measuring activity in the liver and spleen of patients receiving 75 mCi131I-antibody to CEA intravenously. Planar imaging gave significantly higher values than SPET for the spleen (t=5.4,P<0.001 by the pairedt-test) but no significant difference for the liver. SPET with scatter correction forms a basis for an improved technique of quantifying the targeting efficiency. Springer-Verlag, 1990 Emission tomography nationallicence SPET nationallicence Scatter correction nationallicence Radiolabelled antibody nationallicence Targeted therapy nationallicence Green Alan Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross and Westminster Medical School, Fulham Palace Road, W6 8RF, London, UK aut Dewhurst Sarah Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross and Westminster Medical School, Fulham Palace Road, W6 8RF, London, UK aut Begent Richard Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross and Westminster Medical School, Fulham Palace Road, W6 8RF, London, UK aut Bagshawe Kenneth Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross and Westminster Medical School, Fulham Palace Road, W6 8RF, London, UK aut Riggs Simon Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross and Westminster Medical School, Fulham Palace Road, W6 8RF, London, UK aut European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 361-365 0340-6997 16:4-6<361 1990 16 259 https://doi.org/10.1007/BF00842793 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00842793 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Green Alan Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross and Westminster Medical School, Fulham Palace Road, W6 8RF, London, UK aut NATIONALLICENCE 700 1- Dewhurst Sarah Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross and Westminster Medical School, Fulham Palace Road, W6 8RF, London, UK aut NATIONALLICENCE 700 1- Begent Richard Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross and Westminster Medical School, Fulham Palace Road, W6 8RF, London, UK aut NATIONALLICENCE 700 1- Bagshawe Kenneth Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross and Westminster Medical School, Fulham Palace Road, W6 8RF, London, UK aut NATIONALLICENCE 700 1- Riggs Simon Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross and Westminster Medical School, Fulham Palace Road, W6 8RF, London, UK aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/4-6(1990-04-01), 361-365 0340-6997 16:4-6<361 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer