caa a22 4500 465786375 CHVBK 20180323112010.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00998162 doi (NATIONALLICENCE)springer-10.1007/BF00998162 Two lymphoscintigraphic agents compared in vitro and in vivo in rabbit knees [Elektronische Daten] [Steen Nielsen, Bente Pedersen, Eiliv Svalastoga, Dimitrios Vittas, Inge Reiman] Two99mTc-labelled colloidal radiopharmaceuticals [99mTc-albumin colloid (A) and99mTc-rhenium sulfide colloid (B)] were compared in vitro in saline, plasma, and synovial fluid with regard to particle size, radiochemical purity, protein binding level, and stability at varying acidity. The purpose was to compare the two compounds in studies of lymphatic drainage from the knee joint of rabbits. Particle size for A was uniform at about 10 nm, but for B it varied between 40 and 80 nm. The radiochemical purity was lowest for B (90%-95%), with a small fraction of minor particles. B was protein bound, which was only the case for A in joint fluid from synovitic knees. A faster disappearance of A than B was observed from the knee joint, with lesser retention in the regional lymph nodes. A negligible uptake of colloid was seen in the liver. The major fraction of radioactivity absorbed from the knee was excreted in the urine. The differences between in vitro and in vivo stability are probably due to phagocytosis in the synovial membrane. Springer-Verlag, 1990 Albumin colloid nationallicence Lymphoscintigraphy nationallicence Rabbit knee nationallicence Synovial fluid nationallicence Sulfide colloid nationallicence Nielsen Steen Department of Nuclear Medicine, 54P1, Denmark aut Pedersen Bente Isotope Pharmacy, National Board of Health, Denmark aut Svalastoga Eiliv Department of Small Animal Diseases, Royal Veterinary and Agricultural University, Copenhagen, Denmark aut Vittas Dimitrios Department of Orthopedic Surgery, Herlev Hospital, DK-2730, Denmark aut Reiman Inge Department of Orthopedic Surgery, Herlev Hospital, DK-2730, Denmark aut European Journal of Nuclear Medicine Springer-Verlag 16/8-10(1990-08-01), 639-641 0340-6997 16:8-10<639 1990 16 259 https://doi.org/10.1007/BF00998162 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00998162 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nielsen Steen Department of Nuclear Medicine, 54P1, Denmark aut NATIONALLICENCE 700 1- Pedersen Bente Isotope Pharmacy, National Board of Health, Denmark aut NATIONALLICENCE 700 1- Svalastoga Eiliv Department of Small Animal Diseases, Royal Veterinary and Agricultural University, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Vittas Dimitrios Department of Orthopedic Surgery, Herlev Hospital, DK-2730, Denmark aut NATIONALLICENCE 700 1- Reiman Inge Department of Orthopedic Surgery, Herlev Hospital, DK-2730, Denmark aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/8-10(1990-08-01), 639-641 0340-6997 16:8-10<639 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer