caa a22 4500 465786383 CHVBK 20180323112010.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00998160 doi (NATIONALLICENCE)springer-10.1007/BF00998160 Dysprosium (165Dy) hydroxide macroaggregates for radiation synovectomy — animal studies [Elektronische Daten] [Ashley McLaren, Eric Hetherington, Des Maddalena, Graeme Snowdon] This paper reports the development of a new chemical formulation, Dy-HMA, to utilise the advantages of dysprosium 165 in radiation synovectomy of certain forms of arthritis. Dy-HMA is a sterile suspension of dysprosium hydroxide macroaggregates (approximately 6 mg Dy/ml) in saline with the majority of particles in the 3-5 μm range. The absence of ferric hydroxide and a higher concentration of dysprosium in the formulation offer advantages over dysprosium ferric hydroxide macroaggregates, Dy-165-FHMA. Biodistribution studies in rats and rabbits with Dy-HMA show less leakage than with Dy-FHMA and considerably less leakage than with yttrium silicate colloid. Rabbits treated with intraarticular injections of Dy-HMA equivalent to 10-30 times the typical clinical dose showed no signs of any toxic effects. Springer-Verlag, 1990 Dysprosium hydroxide macroaggregates nationallicence Radiation synovectomy nationallicence Preparation nationallicence Biodistribution in rats and rabbits nationallicence Toxicity nationallicence 165Dy nationallicence McLaren Ashley Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Road, Lucas Heights 2234, NSW, Australia aut Hetherington Eric Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Road, Lucas Heights 2234, NSW, Australia aut Maddalena Des Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Road, Lucas Heights 2234, NSW, Australia aut Snowdon Graeme Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Road, Lucas Heights 2234, NSW, Australia aut European Journal of Nuclear Medicine Springer-Verlag 16/8-10(1990-08-01), 627-632 0340-6997 16:8-10<627 1990 16 259 https://doi.org/10.1007/BF00998160 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00998160 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McLaren Ashley Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Road, Lucas Heights 2234, NSW, Australia aut NATIONALLICENCE 700 1- Hetherington Eric Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Road, Lucas Heights 2234, NSW, Australia aut NATIONALLICENCE 700 1- Maddalena Des Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Road, Lucas Heights 2234, NSW, Australia aut NATIONALLICENCE 700 1- Snowdon Graeme Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Road, Lucas Heights 2234, NSW, Australia aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/8-10(1990-08-01), 627-632 0340-6997 16:8-10<627 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer