caa a22 4500 465786510 CHVBK 20180323112010.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF01465915 doi (NATIONALLICENCE)springer-10.1007/BF01465915 Renal uptake of dimercaptosuccinic acid and glomerular filtration rate in chronic nephropathy at angiotensin converting enzyme inhibition [Elektronische Daten] [A. Kamper, H. Thomsen, S. Nielsen, S. Strandgaard] Glomerular filtration rate (GFR) and renal uptake of dimercaptosuccinic acid (DMSA) were measured in 31 patients with progressive chronic nephropathy before and immediately after the start of treatment with angiotensin converting enzyme (ACE) inhibitor in order to control adverse effects on kidney function. Scintigrams of the kidneys showed an unaltered distribution of DMSA during treatment. GFR estimated by51Cr-EDTA plasma clearance fell by 14% (P < 0.01), but renal uptake of99mTc-DMSA increased by 10% (P < 0.01). It is concluded that DMSA in chronic renal failure is mainly taken up by the tubular cells from the peritubular capillaries since the uptake was unaffected by the acute decrease in GFR. Springer-Verlag, 1990 Angiotensin converting enzyme inhibition nationallicence Chronic nephropathy nationallicence Dimercaptosuccinic acid renal uptake nationallicence Kamper A. Departments of Nephrology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark aut Thomsen H. Departments of Nephrology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark aut Nielsen S. Departments of Nephrology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark aut Strandgaard S. Departments of Nephrology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark aut European Journal of Nuclear Medicine Springer-Verlag 16/2(1990-02-01), 85-88 0340-6997 16:2<85 1990 16 259 https://doi.org/10.1007/BF01465915 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01465915 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kamper A. Departments of Nephrology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark aut NATIONALLICENCE 700 1- Thomsen H. Departments of Nephrology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark aut NATIONALLICENCE 700 1- Nielsen S. Departments of Nephrology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark aut NATIONALLICENCE 700 1- Strandgaard S. Departments of Nephrology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/2(1990-02-01), 85-88 0340-6997 16:2<85 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer