caa a22 4500 465786537 CHVBK 20180323112010.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF00833015 doi (NATIONALLICENCE)springer-10.1007/BF00833015 Quantitation of left ventricular asynchrony on radionuclide angiography phase images [Elektronische Daten] [Bruno Alfano, Sandro Betocchi, Leonardo Pace, Pasquale Perrone-Filardi, Massimo Chiariello, Marco Salvatore] Quantitation of left ventricular (LV) asynchrony is relevant in clinical cardiology, as well as in evaluating LV mechanical properties. Radionuclide angiography (RA) phase images are extensively used, and asynchrony is usually assessed by computing the standard deviation of phase angle distribution (SD). However, SD is dependent on count statistics and does not take into account the spatial distribution of asynchrony. In this study a new index to evaluate asynchrony on phase images is presented (differential uniformity parameter, DUP). DUP is based on the frequency analysis of phase images. Diagnostic accuracy and reproducibility of either SD or DUP were tested. Reproducibility was evaluated in 15 patients studied by RA twice within a few minutes. DUP showed a better reproducibility than SD. Diagnostic accuracy was estimated in 84 patients, divided into four subgroups on the basis of coronary arteriography and contrast ventriculography findings: (a) 25 control subjects, (b) 16 patients with coronary artery disease (CAD) and normal LV wall motion, (c) 23 patients with CAD and LV hypokinesia and (d) 20 patients with CAD and LV dyskinesia. Relative diagnostic ability was assessed by comparing the areas under receiver-operating characteristic curves. DUP's area was larger than SD's when group D was tested against all the other groups (DUP's area=87%±5%, SD's area=76%±7%;P<0.01). Thus, our study indicates that DUP is more reproducible and more accurate than SD in identifying patients with CAD and LV dyskinesia. Springer-Verlag, 1990 Asynchrony nationallicence Phase images nationallicence Radionuclide angiography nationallicence Alfano Bruno Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut Betocchi Sandro Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut Pace Leonardo Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut Perrone-Filardi Pasquale Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut Chiariello Massimo Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut Salvatore Marco Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut European Journal of Nuclear Medicine Springer-Verlag 16/11(1990-11-01), 801-806 0340-6997 16:11<801 1990 16 259 https://doi.org/10.1007/BF00833015 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00833015 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alfano Bruno Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut NATIONALLICENCE 700 1- Betocchi Sandro Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut NATIONALLICENCE 700 1- Pace Leonardo Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut NATIONALLICENCE 700 1- Perrone-Filardi Pasquale Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut NATIONALLICENCE 700 1- Chiariello Massimo Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut NATIONALLICENCE 700 1- Salvatore Marco Department of Radiology-Nuclear Medicine and Department of Medicine-Cardiology, University of Naples 2nd School of Medicine, Naples, Italy aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/11(1990-11-01), 801-806 0340-6997 16:11<801 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer