caa a22 4500 465786545 CHVBK 20180323112010.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF00833018 doi (NATIONALLICENCE)springer-10.1007/BF00833018 Where have we got to with neuroreceptor mapping of the human brain? [Elektronische Daten] [B. Mazière, M. Mazière] In the past two decades, tritiated radioligand receptor binding, a tool commonly used to investigate the site of action of drugs in laboratory animals, has provided a vast body of information on neuropharmacology and neurobiology. Several neurological and psychiatric diseases have been related to neurotransmitter and receptor disorders. In order to study ligand interactions with receptors in vivo in humans, new tracers capable of carrying aγ-emitting radionuclide to the receptor have been designed. Emission computerized tomography (ECT) techniques such as positron (PET) or single photon emission tomography (SPET) allow monitoring of the time-course of regional tissue concentration of these radiolabelled ligands. PET and SPET each have their inherent advantages and drawbacks. The cyclotron-based technology of PET is a demanding and expensive technique that, to date, is still mainly reserved for research purposes. It is hoped that once the scientific basis of a physiopathological study is established using PET, diagnostic information might be provided by the more readily available SPET technology. The purpose of this article is to review the current state of receptor-bindingγ-emitting radioligands and to present the clinical potential of these new kinds of radiopharmaceuticals in clinical investigation. Springer-Verlag, 1990 Radioligand receptor binding nationallicence PET nationallicence SPET nationallicence Emission computerized tomography nationallicence Psychiatric illness nationallicence Neurological illness nationallicence Mazière B. Service Hospitalier Frédéric Joliot Commissariat à l'Energie Atomique, F-91406, Orsay, France aut Mazière M. Service Hospitalier Frédéric Joliot Commissariat à l'Energie Atomique, F-91406, Orsay, France aut European Journal of Nuclear Medicine Springer-Verlag 16/11(1990-11-01), 817-835 0340-6997 16:11<817 1990 16 259 https://doi.org/10.1007/BF00833018 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00833018 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mazière B. Service Hospitalier Frédéric Joliot Commissariat à l'Energie Atomique, F-91406, Orsay, France aut NATIONALLICENCE 700 1- Mazière M. Service Hospitalier Frédéric Joliot Commissariat à l'Energie Atomique, F-91406, Orsay, France aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/11(1990-11-01), 817-835 0340-6997 16:11<817 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer