caa a22 4500 46578660X CHVBK 20180323112011.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF00833013 doi (NATIONALLICENCE)springer-10.1007/BF00833013 Blood pool ventriculography with a new technetium-labelled complex (99mTc-DEPIC) [Elektronische Daten] a clinical evaluation [Geoffrey Brigden, Giussepe Zanelli, Avijit Lahiri, Edward Raftery] A new, single bolus method of in vivo blood pool imaging using a technetium Tc99m phosphine isocyanide complex (DEPIC) which binds to pre-albumin was evaluated in volunteers (n=4) and patients (n=20). DEPIC was assessed for its safety and possible drug interactions. Its duration of action and quality of ventriculography were compared with imaging using standard in vivo red cell labelling (PYP) during two 3-h scanning periods 1 week apart. DEPIC had a mean plasma halflife of 3.3 h. The count rate over the left ventricle was initially 42% higher with DEPIC than with PYP. However, removal of DEPIC by the liver resulted in equivalent count rates by 1 h, and by 3 h PYP count rates were 22% higher than DEPIC. Immediately post injection mean (SD) difference in the left ventricular ejection fraction between the two methods was 2.4% (7.7%). Satisfactory DEPIC scans were obtained up to 2 h post injection, but by 3 h there was a mean difference of 13% (11.3%). DEPIC was found to be a safe alternative to red all labelling for blood pool angiography, suitable for routine work. The single bolus methodology and high initial count rates offer improved efficiency and a capability for truly emergency scanning. Springer-Verlag, 1990 99mTc nationallicence Phosphine nationallicence Isocyanide nationallicence Blood pool imaging nationallicence Left ventricular ejection fraction nationallicence Brigden Geoffrey Department of Cardiology, Northwick Park Hospital and Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Zanelli Giussepe Radioisotopes Division, Northwick Park Hospital and Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Lahiri Avijit Department of Cardiology, Northwick Park Hospital and Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Raftery Edward Department of Cardiology, Northwick Park Hospital and Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut European Journal of Nuclear Medicine Springer-Verlag 16/11(1990-11-01), 795-799 0340-6997 16:11<795 1990 16 259 https://doi.org/10.1007/BF00833013 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00833013 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brigden Geoffrey Department of Cardiology, Northwick Park Hospital and Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Zanelli Giussepe Radioisotopes Division, Northwick Park Hospital and Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Lahiri Avijit Department of Cardiology, Northwick Park Hospital and Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Raftery Edward Department of Cardiology, Northwick Park Hospital and Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/11(1990-11-01), 795-799 0340-6997 16:11<795 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer