caa a22 4500 465786634 CHVBK 20180323112011.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF00833017 doi (NATIONALLICENCE)springer-10.1007/BF00833017 In vivo characterisation of 3-iodo-6-methoxybenzamide123I in humans [Elektronische Daten] [D. Costa, N. Verhoeff, I. Cullum, P. Ell, G. Syed, J. Barrett, E. Palazidou, B. Toone, E. Van Royen, M. Bobeldijk] 3-Iodo-6-methoxybenzamide (123I-IBZM), a new Dopamine D2 receptor ligand, was used in conjunction with SME 810 brain tomography to study six subjects (one normal volunteer, four schizophrenics and one DAT patient). Initial Dynamic SPET was followed by multislice SPET. High-resolution images of the D2 receptor distribution in the basal ganglia were obtained. The specific binding in D2 receptors of the basal ganglia is highest from 2-4 h p.i. Patients on anti-psychotic drugs showed significantly lower specific binding. Dopamine D2 brain receptor availability in man may now be studied with SPET. Continuous data acquisition with single slice tomography is particularly important in the study of this type of radiotracers. Springer-Verlag, 1990 Dopamine D2 nationallicence 123I-IBZM nationallicence Dynamic SPET nationallicence Schizophrenia nationallicence Costa D. Institute of Nuclear Medicine, UCMSM, London, UK aut Verhoeff N. University of Amsterdam, The Netherlands aut Cullum I. Institute of Nuclear Medicine, UCMSM, London, UK aut Ell P. Institute of Nuclear Medicine, UCMSM, London, UK aut Syed G. King's College Hospital, London, UK aut Barrett J. King's College Hospital, London, UK aut Palazidou E. King's College Hospital, London, UK aut Toone B. King's College Hospital, London, UK aut Van Royen E. University of Amsterdam, The Netherlands aut Bobeldijk M. Cygne BV, Eindhoven, The Netherlands aut European Journal of Nuclear Medicine Springer-Verlag 16/11(1990-11-01), 813-816 0340-6997 16:11<813 1990 16 259 https://doi.org/10.1007/BF00833017 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00833017 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Costa D. Institute of Nuclear Medicine, UCMSM, London, UK aut NATIONALLICENCE 700 1- Verhoeff N. University of Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Cullum I. Institute of Nuclear Medicine, UCMSM, London, UK aut NATIONALLICENCE 700 1- Ell P. Institute of Nuclear Medicine, UCMSM, London, UK aut NATIONALLICENCE 700 1- Syed G. King's College Hospital, London, UK aut NATIONALLICENCE 700 1- Barrett J. King's College Hospital, London, UK aut NATIONALLICENCE 700 1- Palazidou E. King's College Hospital, London, UK aut NATIONALLICENCE 700 1- Toone B. King's College Hospital, London, UK aut NATIONALLICENCE 700 1- Van Royen E. University of Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Bobeldijk M. Cygne BV, Eindhoven, The Netherlands aut NATIONALLICENCE 773 0- European Journal of Nuclear Medicine Springer-Verlag 16/11(1990-11-01), 813-816 0340-6997 16:11<813 1990 16 259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer