caa a22 4500 465789307 CHVBK 20180323112018.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00216935 doi (NATIONALLICENCE)springer-10.1007/BF00216935 A phase II study of mitoxantrone in advanced squamous cell cancer of the head and neck [Elektronische Daten] [H. Wheeler, R. Woods, J. Page, J. Levi] Summary: Twenty patients with advanced squamous cell carcinomas (SCC) of the head and neck were entered into a phase II study of mitoxantrone at a dosage of either 12 mg/m2 or 14 mg/m2 given at 3 weekly intervals. None of the patients had received prior chemotherapy. One patient had a partial remission. Two patients died from unrelated causes. One patient withdrew from the trial prior to receiving any chemotherapy. Sixteen patients either failed to respond or progressed during the course of the treatment. Side effects included nausea and vomiting in 6 patients and neutropenia in 6 patients. This study failed to detect a significant response of squamous cell carcinomas of the head and neck to mitoxantrone therapy at the described doses. Kluwer Academic Publishers, 1990 mitoxantrone nationallicence head and neck cancer nationallicence phase II nationallicence Wheeler H. Royal North Shore Hospital, Sydney, Australia aut Woods R. Repatriation General Hospital, Concord, Sydney, Australia aut Page J. Repatriation General Hospital, Concord, Sydney, Australia aut Levi J. Royal North Shore Hospital, Sydney, Australia aut Investigational New Drugs Kluwer Academic Publishers 8/1(1990-02-01), 109-111 0167-6997 8:1<109 1990 8 10637 https://doi.org/10.1007/BF00216935 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00216935 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wheeler H. Royal North Shore Hospital, Sydney, Australia aut NATIONALLICENCE 700 1- Woods R. Repatriation General Hospital, Concord, Sydney, Australia aut NATIONALLICENCE 700 1- Page J. Repatriation General Hospital, Concord, Sydney, Australia aut NATIONALLICENCE 700 1- Levi J. Royal North Shore Hospital, Sydney, Australia aut NATIONALLICENCE 773 0- Investigational New Drugs Kluwer Academic Publishers 8/1(1990-02-01), 109-111 0167-6997 8:1<109 1990 8 10637 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer