caa a22 4500 46578934X CHVBK 20180323112018.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00216933 doi (NATIONALLICENCE)springer-10.1007/BF00216933 Aclacinomycin A in the treatment of multiple myeloma: A Southwest Oncology Group study [Elektronische Daten] [Chatchada Karanes, John Crowley, Laxmidas Sawkar, Bill Tranum, William Hicks, John Bonnet, Lyubica Dabich, Bruce Dana, Sydney Salmon] Summary: Fifty-two patients with progressive resistant multiple myeloma were entered in this Southwest Oncology Group Phase II study, using weekly intravenous Aclacinomycin A. Of forty-three evaluable patients for response, there was one partial remission of 2 years duration and two sustained clinical improvements with 25% reduction in paraprotein. Major toxicity seen was severe myelosuppression and significant nausea and vomiting requiring dose reduction and delay of the scheduled treatment. Cardiac arrhythmia was seen in one patient. Chronic daily schedule or continuous IV infusion is recommended for future study. Kluwer Academic Publishers, 1990 Aclacinomycin A nationallicence multiple myeloma nationallicence Karanes Chatchada Wayne State University School of Medicine, USA aut Crowley John Southwest Oncology Group Biostatistical Center, Seattle aut Sawkar Laxmidas Midwest CCOP, USA aut Tranum Bill Arkansas CCOP, USA aut Hicks William Columbus CCOP, USA aut Bonnet John Scott and White Clinic, USA aut Dabich Lyubica University of Michigan Medical Center, USA aut Dana Bruce University of Oregon Health Science Center, USA aut Salmon Sydney University of Arizona Cancer Center, USA aut Investigational New Drugs Kluwer Academic Publishers 8/1(1990-02-01), 101-104 0167-6997 8:1<101 1990 8 10637 https://doi.org/10.1007/BF00216933 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00216933 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karanes Chatchada Wayne State University School of Medicine, USA aut NATIONALLICENCE 700 1- Crowley John Southwest Oncology Group Biostatistical Center, Seattle aut NATIONALLICENCE 700 1- Sawkar Laxmidas Midwest CCOP, USA aut NATIONALLICENCE 700 1- Tranum Bill Arkansas CCOP, USA aut NATIONALLICENCE 700 1- Hicks William Columbus CCOP, USA aut NATIONALLICENCE 700 1- Bonnet John Scott and White Clinic, USA aut NATIONALLICENCE 700 1- Dabich Lyubica University of Michigan Medical Center, USA aut NATIONALLICENCE 700 1- Dana Bruce University of Oregon Health Science Center, USA aut NATIONALLICENCE 700 1- Salmon Sydney University of Arizona Cancer Center, USA aut NATIONALLICENCE 773 0- Investigational New Drugs Kluwer Academic Publishers 8/1(1990-02-01), 101-104 0167-6997 8:1<101 1990 8 10637 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer