caa a22 4500 465789986 CHVBK 20180323112021.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF00198599 doi (NATIONALLICENCE)springer-10.1007/BF00198599 4′ -epi-doxorubicin in advanced lung cancer [Elektronische Daten] A phase II trial [Giuseppe Giaccone, Michela Donadio, Gianmaria Bonardi, Valter Iberti, Alessandro Calciati] Summary: Fifty evaluable patients with advanced lung cancer (28 small cell and 22 non-small cell carcinomas), mainly pretreated by chemotherapy, received 4′-epi-doxorubicin 90 mg/m2 every 3 weeks. Two partial responses were obtained in small cell lung cancer patients, which lasted 153 and 168 days. Leukopenia, emesis and alopecia were the most frequent side effects. Two patients who previously received anthracyclines died suddenly of cardiac failure, another patient had severe congestive heart failure, and four others had minor cardiac dysfunctions. 4′-epi-doxorubicin has a modest activity in advanced lung cancer, mainly pretreated by chemotherapy and is not devoid of significant cardiotoxicity in this patient population. Kluwer Academic Publishers, 1990 lung cancer nationallicence chemotherapy nationallicence epirubicin nationallicence Giaccone Giuseppe Division of Medical Oncology, Ospedale S. Giovanni, A.S., Torino, Italy aut Donadio Michela Division of Medical Oncology, Ospedale S. Giovanni, A.S., Torino, Italy aut Bonardi Gianmaria Division of Medical Oncology, Ospedale S. Giovanni, A.S., Torino, Italy aut Iberti Valter Division of Medical Oncology, Ospedale S. Giovanni, A.S., Torino, Italy aut Calciati Alessandro Division of Medical Oncology, Ospedale S. Giovanni, A.S., Torino, Italy aut Investigational New Drugs Kluwer Academic Publishers 8/4(1990-11-01), 393-396 0167-6997 8:4<393 1990 8 10637 https://doi.org/10.1007/BF00198599 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00198599 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Giaccone Giuseppe Division of Medical Oncology, Ospedale S. Giovanni, A.S., Torino, Italy aut NATIONALLICENCE 700 1- Donadio Michela Division of Medical Oncology, Ospedale S. Giovanni, A.S., Torino, Italy aut NATIONALLICENCE 700 1- Bonardi Gianmaria Division of Medical Oncology, Ospedale S. Giovanni, A.S., Torino, Italy aut NATIONALLICENCE 700 1- Iberti Valter Division of Medical Oncology, Ospedale S. Giovanni, A.S., Torino, Italy aut NATIONALLICENCE 700 1- Calciati Alessandro Division of Medical Oncology, Ospedale S. Giovanni, A.S., Torino, Italy aut NATIONALLICENCE 773 0- Investigational New Drugs Kluwer Academic Publishers 8/4(1990-11-01), 393-396 0167-6997 8:4<393 1990 8 10637 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer