caa a22 4500 465790089 CHVBK 20180323112021.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00177256 doi (NATIONALLICENCE)springer-10.1007/BF00177256 Phase II trial of carboplatin in patients with advanced melanoma [Elektronische Daten] [Ephraim Casper, Dean Bajorin] Summary: We report the results of a phase II evaluation of carboplatin (CBDCA) in 45 patients with advanced malignant melanoma. Of the 43 evaluable patients, 6 had been treated previously with chemotherapy; 11 had been treated with immunotherapy. The initial dose was 400 mg/m2 i.v. every 4 weeks; the dose was modified as required to achieve moderate myelosuppression. There was one complete response (duration 16 months) and six partial responses, for a major objective response rate of 16%. Toxicity consisted primarily of acute nausea and vomiting, and thrombocytopenia. The activity of CBDCA in this disease is similar to that of cisplatin and dacarbazine. Kluwer Academic Publishers, 1990 carboplatin nationallicence melanoma nationallicence Casper Ephraim Solid Tumor Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College New York, NY, USA aut Bajorin Dean Solid Tumor Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College New York, NY, USA aut Investigational New Drugs Kluwer Academic Publishers 8/2(1990-05-01), 187-190 0167-6997 8:2<187 1990 8 10637 https://doi.org/10.1007/BF00177256 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177256 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Casper Ephraim Solid Tumor Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College New York, NY, USA aut NATIONALLICENCE 700 1- Bajorin Dean Solid Tumor Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College New York, NY, USA aut NATIONALLICENCE 773 0- Investigational New Drugs Kluwer Academic Publishers 8/2(1990-05-01), 187-190 0167-6997 8:2<187 1990 8 10637 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer