caa a22 4500 465790143 CHVBK 20180323112021.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00177249 doi (NATIONALLICENCE)springer-10.1007/BF00177249 Antitumor effect of GPA1734 in rat Walker 256 carcinoma [Elektronische Daten] [Eleftheria Missirlis, George Karakiulakis, Michael Maragoudakis] Summary: Inhibition of angiogenesis offers an alternative approach to cancer chemotherapy, since solid tumor growth has an absolute dependency on angiogenesis. We have previously shown that 8,9-dihydroxy-7-methyl-benzo [b]quinolizinium bromide (GPA1734) is a basement membrane synthesis inhibitor, and that this compound acts as an antiangiogenic agent in the chick chorioallantoic membrane. When a piece of 10 mg from a Walker 256 carcinoma was implated into the peritoneal cavity of rats, tumor grew to about 15 g within nine days after transplant. Daily treatment of Walker 256 carcinoma bearing animals with GPA1734, at doses 10-100 mg/kg intraperitoneally, restrained tumor growth in a dose dependent manner. Macroscopic examination showed tumor cells growing in spherical masses 5-8 mm in diameter, indicative of absence of neovascularization. GPA1734 at 300 μM had no direct effect on Walker 256 carcinoma cell culture growth. The antitumor effect of this agent on Walker 256 carcinoma may be related to its antiangiogenic properties. Kluwer Academic Publishers, 1990 antiangiogenic agent nationallicence GPA1734 nationallicence basement membrane collagen nationallicence Missirlis Eleftheria Department of Pharmacology, University of Patras Medical School, Patras, Greece aut Karakiulakis George Department of Pharmacology, University of Patras Medical School, Patras, Greece aut Maragoudakis Michael Department of Pharmacology, University of Patras Medical School, Patras, Greece aut Investigational New Drugs Kluwer Academic Publishers 8/2(1990-05-01), 145-147 0167-6997 8:2<145 1990 8 10637 https://doi.org/10.1007/BF00177249 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177249 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Missirlis Eleftheria Department of Pharmacology, University of Patras Medical School, Patras, Greece aut NATIONALLICENCE 700 1- Karakiulakis George Department of Pharmacology, University of Patras Medical School, Patras, Greece aut NATIONALLICENCE 700 1- Maragoudakis Michael Department of Pharmacology, University of Patras Medical School, Patras, Greece aut NATIONALLICENCE 773 0- Investigational New Drugs Kluwer Academic Publishers 8/2(1990-05-01), 145-147 0167-6997 8:2<145 1990 8 10637 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer